Role of Microglia in CNS Autoimmunity

Multiple sclerosis (MS) is the most common autoimmune disease of the central nervous system (CNS) in the Western world. The disease is characterized histologically by the infiltration of encephalitogenic T(H)1/T(H)17-polarized CD4(+) T cells, B cells, and a plethora of myeloid cells, resulting in se...

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Detalles Bibliográficos
Autores principales: Goldmann, Tobias, Prinz, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694374/
https://www.ncbi.nlm.nih.gov/pubmed/23840238
http://dx.doi.org/10.1155/2013/208093
Descripción
Sumario:Multiple sclerosis (MS) is the most common autoimmune disease of the central nervous system (CNS) in the Western world. The disease is characterized histologically by the infiltration of encephalitogenic T(H)1/T(H)17-polarized CD4(+) T cells, B cells, and a plethora of myeloid cells, resulting in severe demyelination ultimately leading to a degeneration of neuronal structures. These pathological processes are substantially modulated by microglia, the resident immune competent cells of the CNS. In this overview, we summarize the current knowledge regarding the highly diverse and complex function of microglia during CNS autoimmunity in either promoting tissue injury or tissue repair. Hence, understanding microglia involvement in MS offers new exciting paths for therapeutic intervention.

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