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Role of Microglia in CNS Autoimmunity

Multiple sclerosis (MS) is the most common autoimmune disease of the central nervous system (CNS) in the Western world. The disease is characterized histologically by the infiltration of encephalitogenic T(H)1/T(H)17-polarized CD4(+) T cells, B cells, and a plethora of myeloid cells, resulting in se...

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Detalles Bibliográficos
Autores principales: Goldmann, Tobias, Prinz, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694374/
https://www.ncbi.nlm.nih.gov/pubmed/23840238
http://dx.doi.org/10.1155/2013/208093
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author Goldmann, Tobias
Prinz, Marco
author_facet Goldmann, Tobias
Prinz, Marco
author_sort Goldmann, Tobias
collection PubMed
description Multiple sclerosis (MS) is the most common autoimmune disease of the central nervous system (CNS) in the Western world. The disease is characterized histologically by the infiltration of encephalitogenic T(H)1/T(H)17-polarized CD4(+) T cells, B cells, and a plethora of myeloid cells, resulting in severe demyelination ultimately leading to a degeneration of neuronal structures. These pathological processes are substantially modulated by microglia, the resident immune competent cells of the CNS. In this overview, we summarize the current knowledge regarding the highly diverse and complex function of microglia during CNS autoimmunity in either promoting tissue injury or tissue repair. Hence, understanding microglia involvement in MS offers new exciting paths for therapeutic intervention.
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spelling pubmed-36943742013-07-09 Role of Microglia in CNS Autoimmunity Goldmann, Tobias Prinz, Marco Clin Dev Immunol Review Article Multiple sclerosis (MS) is the most common autoimmune disease of the central nervous system (CNS) in the Western world. The disease is characterized histologically by the infiltration of encephalitogenic T(H)1/T(H)17-polarized CD4(+) T cells, B cells, and a plethora of myeloid cells, resulting in severe demyelination ultimately leading to a degeneration of neuronal structures. These pathological processes are substantially modulated by microglia, the resident immune competent cells of the CNS. In this overview, we summarize the current knowledge regarding the highly diverse and complex function of microglia during CNS autoimmunity in either promoting tissue injury or tissue repair. Hence, understanding microglia involvement in MS offers new exciting paths for therapeutic intervention. Hindawi Publishing Corporation 2013 2013-06-12 /pmc/articles/PMC3694374/ /pubmed/23840238 http://dx.doi.org/10.1155/2013/208093 Text en Copyright © 2013 T. Goldmann and M. Prinz. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Goldmann, Tobias
Prinz, Marco
Role of Microglia in CNS Autoimmunity
title Role of Microglia in CNS Autoimmunity
title_full Role of Microglia in CNS Autoimmunity
title_fullStr Role of Microglia in CNS Autoimmunity
title_full_unstemmed Role of Microglia in CNS Autoimmunity
title_short Role of Microglia in CNS Autoimmunity
title_sort role of microglia in cns autoimmunity
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694374/
https://www.ncbi.nlm.nih.gov/pubmed/23840238
http://dx.doi.org/10.1155/2013/208093
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