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Role of Microglia in CNS Autoimmunity
Multiple sclerosis (MS) is the most common autoimmune disease of the central nervous system (CNS) in the Western world. The disease is characterized histologically by the infiltration of encephalitogenic T(H)1/T(H)17-polarized CD4(+) T cells, B cells, and a plethora of myeloid cells, resulting in se...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694374/ https://www.ncbi.nlm.nih.gov/pubmed/23840238 http://dx.doi.org/10.1155/2013/208093 |
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author | Goldmann, Tobias Prinz, Marco |
author_facet | Goldmann, Tobias Prinz, Marco |
author_sort | Goldmann, Tobias |
collection | PubMed |
description | Multiple sclerosis (MS) is the most common autoimmune disease of the central nervous system (CNS) in the Western world. The disease is characterized histologically by the infiltration of encephalitogenic T(H)1/T(H)17-polarized CD4(+) T cells, B cells, and a plethora of myeloid cells, resulting in severe demyelination ultimately leading to a degeneration of neuronal structures. These pathological processes are substantially modulated by microglia, the resident immune competent cells of the CNS. In this overview, we summarize the current knowledge regarding the highly diverse and complex function of microglia during CNS autoimmunity in either promoting tissue injury or tissue repair. Hence, understanding microglia involvement in MS offers new exciting paths for therapeutic intervention. |
format | Online Article Text |
id | pubmed-3694374 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-36943742013-07-09 Role of Microglia in CNS Autoimmunity Goldmann, Tobias Prinz, Marco Clin Dev Immunol Review Article Multiple sclerosis (MS) is the most common autoimmune disease of the central nervous system (CNS) in the Western world. The disease is characterized histologically by the infiltration of encephalitogenic T(H)1/T(H)17-polarized CD4(+) T cells, B cells, and a plethora of myeloid cells, resulting in severe demyelination ultimately leading to a degeneration of neuronal structures. These pathological processes are substantially modulated by microglia, the resident immune competent cells of the CNS. In this overview, we summarize the current knowledge regarding the highly diverse and complex function of microglia during CNS autoimmunity in either promoting tissue injury or tissue repair. Hence, understanding microglia involvement in MS offers new exciting paths for therapeutic intervention. Hindawi Publishing Corporation 2013 2013-06-12 /pmc/articles/PMC3694374/ /pubmed/23840238 http://dx.doi.org/10.1155/2013/208093 Text en Copyright © 2013 T. Goldmann and M. Prinz. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Goldmann, Tobias Prinz, Marco Role of Microglia in CNS Autoimmunity |
title | Role of Microglia in CNS Autoimmunity |
title_full | Role of Microglia in CNS Autoimmunity |
title_fullStr | Role of Microglia in CNS Autoimmunity |
title_full_unstemmed | Role of Microglia in CNS Autoimmunity |
title_short | Role of Microglia in CNS Autoimmunity |
title_sort | role of microglia in cns autoimmunity |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694374/ https://www.ncbi.nlm.nih.gov/pubmed/23840238 http://dx.doi.org/10.1155/2013/208093 |
work_keys_str_mv | AT goldmanntobias roleofmicrogliaincnsautoimmunity AT prinzmarco roleofmicrogliaincnsautoimmunity |