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Role of life events in the presence of colon polyps among African Americans
BACKGROUND: African Americans have disproportionately higher incidence and death rates of colorectal cancer among all ethnic groups in the United States. Several lifestyle factors (e.g. diet, physical activity and alcohol intake) have been suggested as risk factors for colorectal cancer. Stressful l...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694451/ https://www.ncbi.nlm.nih.gov/pubmed/23758671 http://dx.doi.org/10.1186/1471-230X-13-101 |
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author | Ashktorab, Hassan Hassanzadeh Namin, Hassan Taylor, Teletia Williams, Carla Brim, Hassan Mellman, Thomas Shokrani, Babak Holt, Cheryl L Laiyemo, Adeyinka O Nouraie, Mehdi |
author_facet | Ashktorab, Hassan Hassanzadeh Namin, Hassan Taylor, Teletia Williams, Carla Brim, Hassan Mellman, Thomas Shokrani, Babak Holt, Cheryl L Laiyemo, Adeyinka O Nouraie, Mehdi |
author_sort | Ashktorab, Hassan |
collection | PubMed |
description | BACKGROUND: African Americans have disproportionately higher incidence and death rates of colorectal cancer among all ethnic groups in the United States. Several lifestyle factors (e.g. diet, physical activity and alcohol intake) have been suggested as risk factors for colorectal cancer. Stressful life events have also been identified as risk factors for colorectal cancer. The association between stressful life events and colon polyps, which are precursors of colorectal cancer, has yet to be determined. We aimed to evaluate the relationship between stressful life events and the presence of colon polyps and adenomas in African American men and women. METHODS: In this cross-sectional study, 110 participants were recruited from a colon cancer screening program at Howard University Hospital. Participants completed an 82-item Life Events Questionnaire (Norbeck 1984), assessing major events that have occurred in the participants’ life within the past 12 months. Participants also reported whether the event had a positive or negative impact. Three scores were derived (total, positive, and negative). RESULTS: Total life events scores were higher (Median [M] = 29 and Interquartile range [IQR] = 18-43) in patients with one or more polyps compared to patients without polyps (M, IQR = 21,13-38; P = 0.029). Total, positive or negative Life Events scores did not differ significantly between normal and adenoma patients. Total, negative and positive Life Events scores did not differ between patients who underwent diagnostic colonoscopy (symptomatic) and patients who underwent colonoscopy for colon cancer screening (asymptomatic) and patients for surveillance colonoscopies due to a personal history of colon polyps. Linear regression analysis indicated that male gender is associated with 9.0 unit lower total Life Events score (P = 0.025). CONCLUSION: This study suggests that patients who experienced total life events may be at higher risk of having colon polyps and adenomas which indicates an association between stress and the development of colorectal polyps. |
format | Online Article Text |
id | pubmed-3694451 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-36944512013-06-28 Role of life events in the presence of colon polyps among African Americans Ashktorab, Hassan Hassanzadeh Namin, Hassan Taylor, Teletia Williams, Carla Brim, Hassan Mellman, Thomas Shokrani, Babak Holt, Cheryl L Laiyemo, Adeyinka O Nouraie, Mehdi BMC Gastroenterol Research Article BACKGROUND: African Americans have disproportionately higher incidence and death rates of colorectal cancer among all ethnic groups in the United States. Several lifestyle factors (e.g. diet, physical activity and alcohol intake) have been suggested as risk factors for colorectal cancer. Stressful life events have also been identified as risk factors for colorectal cancer. The association between stressful life events and colon polyps, which are precursors of colorectal cancer, has yet to be determined. We aimed to evaluate the relationship between stressful life events and the presence of colon polyps and adenomas in African American men and women. METHODS: In this cross-sectional study, 110 participants were recruited from a colon cancer screening program at Howard University Hospital. Participants completed an 82-item Life Events Questionnaire (Norbeck 1984), assessing major events that have occurred in the participants’ life within the past 12 months. Participants also reported whether the event had a positive or negative impact. Three scores were derived (total, positive, and negative). RESULTS: Total life events scores were higher (Median [M] = 29 and Interquartile range [IQR] = 18-43) in patients with one or more polyps compared to patients without polyps (M, IQR = 21,13-38; P = 0.029). Total, positive or negative Life Events scores did not differ significantly between normal and adenoma patients. Total, negative and positive Life Events scores did not differ between patients who underwent diagnostic colonoscopy (symptomatic) and patients who underwent colonoscopy for colon cancer screening (asymptomatic) and patients for surveillance colonoscopies due to a personal history of colon polyps. Linear regression analysis indicated that male gender is associated with 9.0 unit lower total Life Events score (P = 0.025). CONCLUSION: This study suggests that patients who experienced total life events may be at higher risk of having colon polyps and adenomas which indicates an association between stress and the development of colorectal polyps. BioMed Central 2013-06-12 /pmc/articles/PMC3694451/ /pubmed/23758671 http://dx.doi.org/10.1186/1471-230X-13-101 Text en Copyright © 2013 Ashktorab et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Ashktorab, Hassan Hassanzadeh Namin, Hassan Taylor, Teletia Williams, Carla Brim, Hassan Mellman, Thomas Shokrani, Babak Holt, Cheryl L Laiyemo, Adeyinka O Nouraie, Mehdi Role of life events in the presence of colon polyps among African Americans |
title | Role of life events in the presence of colon polyps among African Americans |
title_full | Role of life events in the presence of colon polyps among African Americans |
title_fullStr | Role of life events in the presence of colon polyps among African Americans |
title_full_unstemmed | Role of life events in the presence of colon polyps among African Americans |
title_short | Role of life events in the presence of colon polyps among African Americans |
title_sort | role of life events in the presence of colon polyps among african americans |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694451/ https://www.ncbi.nlm.nih.gov/pubmed/23758671 http://dx.doi.org/10.1186/1471-230X-13-101 |
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