Role of platelet chemokines, PF-4 and CTAP-III, in cancer biology

With the recent addition of anti-angiogenic agents to cancer treatment, the angiogenesis regulators in platelets are gaining importance. Platelet factor 4 (PF-4/CXCL4) and Connective tissue activating peptide III (CTAP-III) are two platelet-associated chemokines that modulate tumor angiogenesis, inf...

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Autores principales: Pilatova, Katerina, Greplova, Kristina, Demlova, Regina, Bencsikova, Beatrix, Klement, Giannoula Lakka, Zdrazilova-Dubska, Lenka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694472/
https://www.ncbi.nlm.nih.gov/pubmed/23800319
http://dx.doi.org/10.1186/1756-8722-6-42
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author Pilatova, Katerina
Greplova, Kristina
Demlova, Regina
Bencsikova, Beatrix
Klement, Giannoula Lakka
Zdrazilova-Dubska, Lenka
author_facet Pilatova, Katerina
Greplova, Kristina
Demlova, Regina
Bencsikova, Beatrix
Klement, Giannoula Lakka
Zdrazilova-Dubska, Lenka
author_sort Pilatova, Katerina
collection PubMed
description With the recent addition of anti-angiogenic agents to cancer treatment, the angiogenesis regulators in platelets are gaining importance. Platelet factor 4 (PF-4/CXCL4) and Connective tissue activating peptide III (CTAP-III) are two platelet-associated chemokines that modulate tumor angiogenesis, inflammation within the tumor microenvironment, and in turn tumor growth. Here, we review the role of PF-4 and CTAP-III in the regulation of tumor angiogenesis; the results of clinical trial using recombinant PF-4 (rPF-4); and the use of PF-4 and CTAP-III as cancer biomarkers.
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spelling pubmed-36944722013-06-28 Role of platelet chemokines, PF-4 and CTAP-III, in cancer biology Pilatova, Katerina Greplova, Kristina Demlova, Regina Bencsikova, Beatrix Klement, Giannoula Lakka Zdrazilova-Dubska, Lenka J Hematol Oncol Review With the recent addition of anti-angiogenic agents to cancer treatment, the angiogenesis regulators in platelets are gaining importance. Platelet factor 4 (PF-4/CXCL4) and Connective tissue activating peptide III (CTAP-III) are two platelet-associated chemokines that modulate tumor angiogenesis, inflammation within the tumor microenvironment, and in turn tumor growth. Here, we review the role of PF-4 and CTAP-III in the regulation of tumor angiogenesis; the results of clinical trial using recombinant PF-4 (rPF-4); and the use of PF-4 and CTAP-III as cancer biomarkers. BioMed Central 2013-06-24 /pmc/articles/PMC3694472/ /pubmed/23800319 http://dx.doi.org/10.1186/1756-8722-6-42 Text en Copyright © 2013 Pilatova et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Pilatova, Katerina
Greplova, Kristina
Demlova, Regina
Bencsikova, Beatrix
Klement, Giannoula Lakka
Zdrazilova-Dubska, Lenka
Role of platelet chemokines, PF-4 and CTAP-III, in cancer biology
title Role of platelet chemokines, PF-4 and CTAP-III, in cancer biology
title_full Role of platelet chemokines, PF-4 and CTAP-III, in cancer biology
title_fullStr Role of platelet chemokines, PF-4 and CTAP-III, in cancer biology
title_full_unstemmed Role of platelet chemokines, PF-4 and CTAP-III, in cancer biology
title_short Role of platelet chemokines, PF-4 and CTAP-III, in cancer biology
title_sort role of platelet chemokines, pf-4 and ctap-iii, in cancer biology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694472/
https://www.ncbi.nlm.nih.gov/pubmed/23800319
http://dx.doi.org/10.1186/1756-8722-6-42
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