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Expression of parathyroid hormone-related protein confers malignant potential to mucoepidermoid carcinoma

Parathyroid hormone-related protein (PTHrP) is known to induce bone resorption by activating RANKL as well as PTH. PTHrP plays a central role in humoral hypercalcemia, and its expression has been reported to be closely associated with bone metastasis of breast carcinoma. PTHrP expression in oral squ...

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Autores principales: NAGAMINE, KYOSUKE, KITAMURA, TETSUYA, YANAGAWA-MATSUDA, AYA, OHIRO, YOICHI, TEI, KANCHU, HIDA, KYOKO, HIGASHINO, FUMIHIRO, TOTSUKA, YASUNORI, SHINDOH, MASANOBU
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694618/
https://www.ncbi.nlm.nih.gov/pubmed/23588777
http://dx.doi.org/10.3892/or.2013.2393
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author NAGAMINE, KYOSUKE
KITAMURA, TETSUYA
YANAGAWA-MATSUDA, AYA
OHIRO, YOICHI
TEI, KANCHU
HIDA, KYOKO
HIGASHINO, FUMIHIRO
TOTSUKA, YASUNORI
SHINDOH, MASANOBU
author_facet NAGAMINE, KYOSUKE
KITAMURA, TETSUYA
YANAGAWA-MATSUDA, AYA
OHIRO, YOICHI
TEI, KANCHU
HIDA, KYOKO
HIGASHINO, FUMIHIRO
TOTSUKA, YASUNORI
SHINDOH, MASANOBU
author_sort NAGAMINE, KYOSUKE
collection PubMed
description Parathyroid hormone-related protein (PTHrP) is known to induce bone resorption by activating RANKL as well as PTH. PTHrP plays a central role in humoral hypercalcemia, and its expression has been reported to be closely associated with bone metastasis of breast carcinoma. PTHrP expression in oral squamous carcinoma cell lines was investigated, and PTHrP was expressed in oral squamous cell carcinoma cell lines similar to that in a prostate carcinoma cell line. Mucoepidermoid carcinoma is the most common malignant salivary gland tumor composed of different types of cells including a squamous component. Its clinical behavior is highly variable and ranges from slow-growing and indolent to locally aggressive and highly metastatic. We examined the PTHrP expression in mucoepidermoid carcinoma and assessed the significance of its correlation with clinicopathological features. Immunohistochemical detection of PTHrP was carried out in 21 cases of mucoepidermoid carcinoma in the head and neck region. PTHrP was highly detectable in intermediate and epidermoid cells, and abundant expression of PTHrP in intermediate cells had a significant association with cancer malignancy, including lymph node metastasis and/or tumor recurrence. These results suggest that PTHrP expression can be used as a prognostic factor for mucoepidermoid carcinoma.
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spelling pubmed-36946182013-06-27 Expression of parathyroid hormone-related protein confers malignant potential to mucoepidermoid carcinoma NAGAMINE, KYOSUKE KITAMURA, TETSUYA YANAGAWA-MATSUDA, AYA OHIRO, YOICHI TEI, KANCHU HIDA, KYOKO HIGASHINO, FUMIHIRO TOTSUKA, YASUNORI SHINDOH, MASANOBU Oncol Rep Articles Parathyroid hormone-related protein (PTHrP) is known to induce bone resorption by activating RANKL as well as PTH. PTHrP plays a central role in humoral hypercalcemia, and its expression has been reported to be closely associated with bone metastasis of breast carcinoma. PTHrP expression in oral squamous carcinoma cell lines was investigated, and PTHrP was expressed in oral squamous cell carcinoma cell lines similar to that in a prostate carcinoma cell line. Mucoepidermoid carcinoma is the most common malignant salivary gland tumor composed of different types of cells including a squamous component. Its clinical behavior is highly variable and ranges from slow-growing and indolent to locally aggressive and highly metastatic. We examined the PTHrP expression in mucoepidermoid carcinoma and assessed the significance of its correlation with clinicopathological features. Immunohistochemical detection of PTHrP was carried out in 21 cases of mucoepidermoid carcinoma in the head and neck region. PTHrP was highly detectable in intermediate and epidermoid cells, and abundant expression of PTHrP in intermediate cells had a significant association with cancer malignancy, including lymph node metastasis and/or tumor recurrence. These results suggest that PTHrP expression can be used as a prognostic factor for mucoepidermoid carcinoma. D.A. Spandidos 2013-06 2013-04-08 /pmc/articles/PMC3694618/ /pubmed/23588777 http://dx.doi.org/10.3892/or.2013.2393 Text en Copyright © 2013, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
NAGAMINE, KYOSUKE
KITAMURA, TETSUYA
YANAGAWA-MATSUDA, AYA
OHIRO, YOICHI
TEI, KANCHU
HIDA, KYOKO
HIGASHINO, FUMIHIRO
TOTSUKA, YASUNORI
SHINDOH, MASANOBU
Expression of parathyroid hormone-related protein confers malignant potential to mucoepidermoid carcinoma
title Expression of parathyroid hormone-related protein confers malignant potential to mucoepidermoid carcinoma
title_full Expression of parathyroid hormone-related protein confers malignant potential to mucoepidermoid carcinoma
title_fullStr Expression of parathyroid hormone-related protein confers malignant potential to mucoepidermoid carcinoma
title_full_unstemmed Expression of parathyroid hormone-related protein confers malignant potential to mucoepidermoid carcinoma
title_short Expression of parathyroid hormone-related protein confers malignant potential to mucoepidermoid carcinoma
title_sort expression of parathyroid hormone-related protein confers malignant potential to mucoepidermoid carcinoma
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694618/
https://www.ncbi.nlm.nih.gov/pubmed/23588777
http://dx.doi.org/10.3892/or.2013.2393
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