Budding Yeast ATM/ATR Control Meiotic Double-Strand Break (DSB) Levels by Down-Regulating Rec114, an Essential Component of the DSB-machinery

An essential feature of meiosis is Spo11 catalysis of programmed DNA double strand breaks (DSBs). Evidence suggests that the number of DSBs generated per meiosis is genetically determined and that this ability to maintain a pre-determined DSB level, or “DSB homeostasis”, might be a property of the m...

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Detalles Bibliográficos
Autores principales: Carballo, Jesús A., Panizza, Silvia, Serrentino, Maria Elisabetta, Johnson, Anthony L., Geymonat, Marco, Borde, Valérie, Klein, Franz, Cha, Rita S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694840/
https://www.ncbi.nlm.nih.gov/pubmed/23825959
http://dx.doi.org/10.1371/journal.pgen.1003545

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