Cargando…

Synthetic RNA Silencing of Actinorhodin Biosynthesis in Streptomyces coelicolor A3(2)

We demonstrate the first application of synthetic RNA gene silencers in Streptomyces coelicolor A3(2). Peptide nucleic acid and expressed antisense RNA silencers successfully inhibited actinorhodin production. Synthetic RNA silencing was target-specific and is a new tool for gene regulation and meta...

Descripción completa

Detalles Bibliográficos
Autores principales:	Uguru, Gabriel C., Mondhe, Madhav, Goh, Shan, Hesketh, Andrew, Bibb, Mervyn J., Good, Liam, Stach, James E. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694883/ https://www.ncbi.nlm.nih.gov/pubmed/23826310 http://dx.doi.org/10.1371/journal.pone.0067509

Ejemplares similares

Synthetic Promoter Library for Modulation of Actinorhodin Production in Streptomyces coelicolor A3(2)
por: Sohoni, Sujata Vijay, et al.
Publicado: (2014)

Myxococcus xanthus induces actinorhodin overproduction and aerial mycelium formation by Streptomyces coelicolor
por: Pérez, Juana, et al.
Publicado: (2011)

A Two-Step Mechanism for the Activation of Actinorhodin Export and Resistance in Streptomyces coelicolor
por: Xu, Ye, et al.
Publicado: (2012)

Multi-Omics Analysis of the Effect of cAMP on Actinorhodin Production in Streptomyces coelicolor
por: Nitta, Katsuaki, et al.
Publicado: (2020)

Genome-Wide Mutagenesis Links Multiple Metabolic Pathways with Actinorhodin Production in Streptomyces coelicolor
por: Xu, Zhong, et al.
Publicado: (2019)

LAL Regulators SCO0877 and SCO7173 as Pleiotropic Modulators of Phosphate Starvation Response and Actinorhodin Biosynthesis in Streptomyces coelicolor
por: Guerra, Susana M., et al.
Publicado: (2012)

Mechanism of CuO nano-particles on stimulating production of actinorhodin in Streptomyces coelicolor by transcriptional analysis
por: Liu, Xiaomei, et al.
Publicado: (2019)

The SCO1731 methyltransferase modulates actinorhodin production and morphological differentiation of Streptomyces coelicolor A3(2)
por: Pisciotta, Annalisa, et al.
Publicado: (2018)

Sulfane sulfur‐activated actinorhodin production and sporulation is maintained by a natural gene circuit in Streptomyces coelicolor
por: Lu, Ting, et al.
Publicado: (2020)

Evidence of a role for CutRS and actinorhodin in the secretion stress response in Streptomyces coelicolor M145
por: McLean, Thomas C., et al.
Publicado: (2023)

Engineering Streptomyces coelicolor for heterologous expression of secondary metabolite gene clusters
por: Gomez‐Escribano, Juan Pablo, et al.
Publicado: (2011)

The global role of ppGpp synthesis in morphological differentiation and antibiotic production in Streptomyces coelicolor A3(2)
por: Hesketh, Andrew, et al.
Publicado: (2007)

Sulfane Sulfur Posttranslationally Modifies the Global Regulator AdpA to Influence Actinorhodin Production and Morphological Differentiation of Streptomyces coelicolor
por: Lu, Ting, et al.
Publicado: (2022)

In vivo DNase I sensitivity of the Streptomyces coelicolor chromosome correlates with gene expression: implications for bacterial chromosome structure
por: McArthur, Michael, et al.
Publicado: (2006)

Species-Selective Killing of Bacteria by Antimicrobial Peptide-PNAs
por: Mondhe, Madhav, et al.
Publicado: (2014)

A Streptomyces coelicolor host for the heterologous expression of Type III polyketide synthase genes
por: Thanapipatsiri, Anyarat, et al.
Publicado: (2015)

The Streptomyces coelicolor Small ORF trpM Stimulates Growth and Morphological Development and Exerts Opposite Effects on Actinorhodin and Calcium-Dependent Antibiotic Production
por: Vassallo, Alberto, et al.
Publicado: (2020)

Synthetic RNA Silencing in Bacteria – Antimicrobial Discovery and Resistance Breaking
por: Good, Liam, et al.
Publicado: (2011)

De novo biosynthesis of myricetin, kaempferol and quercetin in Streptomyces albus and Streptomyces coelicolor
por: Marín, Laura, et al.
Publicado: (2018)

Actinorhodin Biosynthesis Terminates with an Unprecedented Biaryl Coupling Reaction
por: Hashimoto, Makoto, et al.
Publicado: (2022)

Crystallization and preliminary X-ray analysis of AbsC, a novel regulator of antibiotic production in Streptomyces coelicolor
por: Stevenson, Clare E. M., et al.
Publicado: (2007)

Carbon-Flux Distribution within Streptomyces coelicolor Metabolism: A Comparison between the Actinorhodin-Producing Strain M145 and Its Non-Producing Derivative M1146
por: Coze, Fabien, et al.
Publicado: (2013)

New Insights into Chloramphenicol Biosynthesis in Streptomyces venezuelae ATCC 10712
por: Fernández-Martínez, Lorena T., et al.
Publicado: (2014)

A Bistable Gene Switch for Antibiotic Biosynthesis: The Butyrolactone Regulon in Streptomyces coelicolor
por: Mehra, Sarika, et al.
Publicado: (2008)

A BioBricks Metabolic Engineering Platform for the Biosynthesis of Anthracyclinones in Streptomyces coelicolor
por: Wang, Rongbin, et al.
Publicado: (2022)

A novel mechanism of immunity controls the onset of cinnamycin biosynthesis in Streptomyces cinnamoneus DSM 40646
por: O’Rourke, Sean, et al.
Publicado: (2016)

OBSERVATIONS ON THE CHROMATINIC BODIES OF Streptomyces coelicolor
por: Hopwood, David A., et al.
Publicado: (1960)

Proteomic survey of the Streptomyces coelicolor nucleoid
por: Bradshaw, Elizabeth, et al.
Publicado: (2013)

Iron competition triggers antibiotic biosynthesis in Streptomyces coelicolor during coculture with Myxococcus xanthus
por: Lee, Namil, et al.
Publicado: (2020)

Engineering a Streptomyces coelicolor biosynthesis pathway into Escherichia coli for high yield triglyceride production
por: Comba, Santiago, et al.
Publicado: (2014)

Identification and physiological characterization of phosphatidic acid phosphatase enzymes involved in triacylglycerol biosynthesis in Streptomyces coelicolor
por: Comba, Santiago, et al.
Publicado: (2013)

Analysis of gene expression in operons of Streptomyces coelicolor
por: Laing, Emma, et al.
Publicado: (2006)

A Membranous Component of the Cytoplasm in Streptomyces coelicolor
por: Glauert, Audrey M., et al.
Publicado: (1959)

Small non-coding RNAs in Streptomyces coelicolor
por: Swiercz, Julia P., et al.
Publicado: (2008)

The dynamic architecture of the metabolic switch in Streptomyces coelicolor
por: Nieselt, Kay, et al.
Publicado: (2010)

Streptomyces coelicolor Vesicles: Many Molecules To Be Delivered
por: Faddetta, Teresa, et al.
Publicado: (2022)

Prodiginines Postpone the Onset of Sporulation in Streptomyces coelicolor
por: Tenconi, Elodie, et al.
Publicado: (2020)

Heterologous expression and purification of encapsulins in Streptomyces coelicolor
por: Andreas, Michael P., et al.
Publicado: (2022)

Abyssomicin Biosynthesis: Formation of an Unusual Polyketide, Antibiotic-Feeding Studies and Genetic Analysis
por: Gottardi, Elvira M, et al.
Publicado: (2011)

Identification and Heterologous Expression of the Chaxamycin Biosynthesis Gene Cluster from Streptomyces leeuwenhoekii
por: Castro, Jean Franco, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_dji3vlkjrkevmvjo6bm3vvhlsg