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EZH2-Mediated H3K27me3 Is Involved in Epigenetic Repression of Deleted in Liver Cancer 1 in Human Cancers

Enhancer of zeste homolog 2 (EZH2), the histone methyltransferase of the Polycomb Repressive complex 2 catalyzing histone H3 lysine 27 tri-methylation (H3K27me3), is frequently up-regulated in human cancers. In this study, we identified the tumor suppressor Deleted in liver cancer 1 (DLC1) as a targ...

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Detalles Bibliográficos
Autores principales:	Au, Sandy Leung-Kuen, Wong, Carmen Chak-Lui, Lee, Joyce Man-Fong, Wong, Chun-Ming, Ng, Irene Oi-Lin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694912/ https://www.ncbi.nlm.nih.gov/pubmed/23826380 http://dx.doi.org/10.1371/journal.pone.0068226

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