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Improving Adaptive and Memory Immune Responses of an HIV/AIDS Vaccine Candidate MVA-B by Deletion of Vaccinia Virus Genes (C6L and K7R) Blocking Interferon Signaling Pathways

Poxvirus vector Modified Vaccinia Virus Ankara (MVA) expressing HIV-1 Env, Gag, Pol and Nef antigens from clade B (termed MVA-B) is a promising HIV/AIDS vaccine candidate, as confirmed from results obtained in a prophylactic phase I clinical trial in humans. To improve the immunogenicity elicited by...

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Detalles Bibliográficos
Autores principales:	García-Arriaza, Juan, Arnáez, Pilar, Gómez, Carmen E., Sorzano, Carlos Óscar S., Esteban, Mariano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694958/ https://www.ncbi.nlm.nih.gov/pubmed/23826170 http://dx.doi.org/10.1371/journal.pone.0066894

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