P2X7 Cell Death Receptor Activation and Mitochondrial Impairment in Oxaliplatin-Induced Apoptosis and Neuronal Injury: Cellular Mechanisms and In Vivo Approach

Limited information is available regarding the cellular mechanisms of oxaliplatin-induced painful neuropathy during exposure of patients to this drug. We therefore determined oxidative stress in cultured cells and evaluated its occurrence in C57BL/6 mice. Using both cultured neuroblastoma (SH-SY5Y)...

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Detalles Bibliográficos
Autores principales: Massicot, France, Hache, Guillaume, David, Ludivine, Chen, Dominique, Leuxe, Charlotte, Garnier-Legrand, Laure, Rat, Patrice, Laprévote, Olivier, Coudoré, François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695015/
https://www.ncbi.nlm.nih.gov/pubmed/23826152
http://dx.doi.org/10.1371/journal.pone.0066830

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