Circulating miRNAs: cell–cell communication function?

Nuclease resistant extracellular miRNAs have been found in all known biological fluids. The biological function of extracellular miRNAs remains questionable; however, strong evidence suggests that these miRNAs can be more than just byproducts of cellular activity. Some extracellular miRNA species mi...

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Detalles Bibliográficos
Autores principales: Turchinovich, A., Samatov, T. R., Tonevitsky, A. G., Burwinkel, B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695387/
https://www.ncbi.nlm.nih.gov/pubmed/23825476
http://dx.doi.org/10.3389/fgene.2013.00119
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author Turchinovich, A.
Samatov, T. R.
Tonevitsky, A. G.
Burwinkel, B.
author_facet Turchinovich, A.
Samatov, T. R.
Tonevitsky, A. G.
Burwinkel, B.
author_sort Turchinovich, A.
collection PubMed
description Nuclease resistant extracellular miRNAs have been found in all known biological fluids. The biological function of extracellular miRNAs remains questionable; however, strong evidence suggests that these miRNAs can be more than just byproducts of cellular activity. Some extracellular miRNA species might carry cell–cell signaling function during various physiological and pathological processes. In this review, we discuss the state-of-the-art in the field of intercellular miRNA transport and highlight current theories regarding the origin and the biological function of extracellular miRNAs.
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spelling pubmed-36953872013-07-02 Circulating miRNAs: cell–cell communication function? Turchinovich, A. Samatov, T. R. Tonevitsky, A. G. Burwinkel, B. Front Genet Genetics Nuclease resistant extracellular miRNAs have been found in all known biological fluids. The biological function of extracellular miRNAs remains questionable; however, strong evidence suggests that these miRNAs can be more than just byproducts of cellular activity. Some extracellular miRNA species might carry cell–cell signaling function during various physiological and pathological processes. In this review, we discuss the state-of-the-art in the field of intercellular miRNA transport and highlight current theories regarding the origin and the biological function of extracellular miRNAs. Frontiers Media S.A. 2013-06-28 /pmc/articles/PMC3695387/ /pubmed/23825476 http://dx.doi.org/10.3389/fgene.2013.00119 Text en Copyright © 2013 Turchinovich, Samatov, Tonevitsky and Burwinkel. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Genetics
Turchinovich, A.
Samatov, T. R.
Tonevitsky, A. G.
Burwinkel, B.
Circulating miRNAs: cell–cell communication function?
title Circulating miRNAs: cell–cell communication function?
title_full Circulating miRNAs: cell–cell communication function?
title_fullStr Circulating miRNAs: cell–cell communication function?
title_full_unstemmed Circulating miRNAs: cell–cell communication function?
title_short Circulating miRNAs: cell–cell communication function?
title_sort circulating mirnas: cell–cell communication function?
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695387/
https://www.ncbi.nlm.nih.gov/pubmed/23825476
http://dx.doi.org/10.3389/fgene.2013.00119
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