The DEAD-box helicase DDX3 substitutes for the cap-binding protein eIF4E to promote compartmentalized translation initiation of the HIV-1 genomic RNA

Here, we show a novel molecular mechanism promoted by the DEAD-box RNA helicase DDX3 for translation of the HIV-1 genomic RNA. This occurs through the adenosine triphosphate-dependent formation of a translation initiation complex that is assembled at the 5′ m(7)GTP cap of the HIV-1 mRNA. This is due...

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Detalles Bibliográficos
Autores principales: Soto-Rifo, Ricardo, Rubilar, Paulina S., Ohlmann, Théophile
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695493/
https://www.ncbi.nlm.nih.gov/pubmed/23630313
http://dx.doi.org/10.1093/nar/gkt306

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