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Molecular basis for improved gene silencing by Dicer substrate interfering RNA compared with other siRNA variants

The canonical exogenous trigger of RNA interference (RNAi) in mammals is small interfering RNA (siRNA). One promising application of RNAi is siRNA-based therapeutics, and therefore the optimization of siRNA efficacy is an important consideration. To reduce unfavorable properties of canonical 21mer s...

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Detalles Bibliográficos
Autores principales:	Snead, Nicholas M., Wu, Xiwei, Li, Arthur, Cui, Qi, Sakurai, Kumi, Burnett, John C., Rossi, John J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2013
Materias:	RNA
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695504/ https://www.ncbi.nlm.nih.gov/pubmed/23620279 http://dx.doi.org/10.1093/nar/gkt200

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