Rapid Assessment of Homogeneity and Stability of Amorphous Solid Dispersions by Atomic Force Microscopy—From Bench to Batch

PURPOSE: To verify the robustness and fundamental value of Atomic Force Microscopy (AFM) and AFM-based assays to rapidly examine the molecular homogeneity and physical stability of amorphous solid dispersions on Hot-Melt-Extrudates. METHODS: Amorphous solid dispersions were prepared with a Hot-Melt...

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Detalles Bibliográficos
Autores principales: Lauer, Matthias E., Siam, Monira, Tardio, Joseph, Page, Susanne, Kindt, Johannes H., Grassmann, Olaf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695673/
https://www.ncbi.nlm.nih.gov/pubmed/23673553
http://dx.doi.org/10.1007/s11095-013-1045-0

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