Cargando…

Hypersusceptibility mechanism of Tenofovir-resistant HIV to EFdA

BACKGROUND: The K65R substitution in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) is the major resistance mutation selected in patients treated with first-line antiretroviral tenofovir disoproxil fumarate (TDF). 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA), is the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Michailidis, Eleftherios, Ryan, Emily M, Hachiya, Atsuko, Kirby, Karen A, Marchand, Bruno, Leslie, Maxwell D, Huber, Andrew D, Ong, Yee T, Jackson, Jacob C, Singh, Kamalendra, Kodama, Eiichi N, Mitsuya, Hiroaki, Parniak, Michael A, Sarafianos, Stefan G
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695782/ https://www.ncbi.nlm.nih.gov/pubmed/23800377 http://dx.doi.org/10.1186/1742-4690-10-65

Ejemplares similares

Efficient Inhibition of HIV Replication in the Gastrointestinal and Female Reproductive Tracts of Humanized BLT Mice by EFdA
por: Shanmugasundaram, Uma, et al.
Publicado: (2016)

K70Q Adds High-Level Tenofovir Resistance to “Q151M Complex” HIV Reverse Transcriptase through the Enhanced Discrimination Mechanism
por: Hachiya, Atsuko, et al.
Publicado: (2011)

EFdA efficiently suppresses HIV replication in the male genital tract and prevents penile HIV acquisition
por: Kovarova, Martina, et al.
Publicado: (2023)

Structural Aspects of Drug Resistance and Inhibition of HIV-1 Reverse Transcriptase
por: Singh, Kamalendra, et al.
Publicado: (2010)

Cellular HIV Reservoirs and Viral Rebound from the Lymphoid Compartments of 4′-Ethynyl-2-Fluoro-2′-Deoxyadenosine (EFdA)-Suppressed Humanized Mice
por: Maidji, Ekaterina, et al.
Publicado: (2019)

Biochemical, inhibition and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase
por: Ndongwe, Tanyaradzwa P., et al.
Publicado: (2012)

Drug Resistance in Non-B Subtype HIV-1: Impact of HIV-1 Reverse Transcriptase Inhibitors
por: Singh, Kamalendra, et al.
Publicado: (2014)

HIV-1 Resistance to Islatravir/Tenofovir Combination Therapy in Wild-Type or NRTI-Resistant Strains of Diverse HIV-1 Subtypes
por: Cilento, Maria E., et al.
Publicado: (2023)

FURTHER STUDIES ON BACTERIAL HYPERSUSCEPTIBILITY. II
por: Zinsser, Hans, et al.
Publicado: (1923)

Biochemical mechanism of clinical resistance to rilpivirine
por: Singh, Kamalendra, et al.
Publicado: (2012)

CFTR Depletion Confers Hypersusceptibility to Mycobacterium fortuitum in a Zebrafish Model
por: Johansen, Matt D., et al.
Publicado: (2020)

Paradoxical Hypersusceptibility of Drug-resistant Mycobacteriumtuberculosis to β-lactam Antibiotics
por: Cohen, Keira A., et al.
Publicado: (2016)

It’s Not You, It’s Me: Medicago truncatula efd-1 Mutant Phenotype Depends on Rhizobium Symbiont
por: Larrainzar, Estíbaliz
Publicado: (2022)

Depletion of neutrophil extracellular traps in vivo results in hypersusceptibility to polymicrobial sepsis in mice
por: Meng, Wei, et al.
Publicado: (2012)

The Hepatitis B Virus Ribonuclease H Is Sensitive to Inhibitors of the Human Immunodeficiency Virus Ribonuclease H and Integrase Enzymes
por: Tavis, John E., et al.
Publicado: (2013)

Inhibitors of Foot and Mouth Disease Virus Targeting a Novel Pocket of the RNA-Dependent RNA Polymerase
por: Durk, Ryan C., et al.
Publicado: (2010)

Haemin deprivation renders Bacteroides fragilis hypersusceptible to metronidazole and cancels high-level metronidazole resistance
por: Paunkov, Ana, et al.
Publicado: (2022)

The Role of ArlRS and VraSR in Regulating Ceftaroline Hypersusceptibility in Methicillin-Resistant Staphylococcus aureus
por: Villanueva, Maite, et al.
Publicado: (2021)

Fabrication of a Large-Area, Fused Polymer Micromold Based on Electric-Field-Driven (EFD) μ-3D Printing
por: Peng, Zilong, et al.
Publicado: (2019)

lptG contributes to changes in membrane permeability and the emergence of multidrug hypersusceptibility in a cystic fibrosis isolate of Pseudomonas aeruginosa
por: Harrison, Lucas B., et al.
Publicado: (2019)

The mutation T477A in HIV-1 reverse transcriptase (RT) restores normal proteolytic processing of RT in virus with Gag-Pol mutated in the p51-RNH cleavage site
por: Abram, Michael E, et al.
Publicado: (2010)

Mechanisms of Action of the Host-Targeting Agent Cyclosporin A and Direct-Acting Antiviral Agents against Hepatitis C Virus
por: Liu, Dandan, et al.
Publicado: (2023)

Deletion of IL-4 Receptor Alpha on Dendritic Cells Renders BALB/c Mice Hypersusceptible to Leishmania major Infection
por: Hurdayal, Ramona, et al.
Publicado: (2013)

When a knockout is an Achilles’ heel: Resistance to one potyvirus species triggers hypersusceptibility to another one in Arabidopsis thaliana
por: Zafirov, Delyan, et al.
Publicado: (2020)

Targeted Genome Reduction of Pseudomonas aeruginosa Strain PAO1 Led to the Development of Hypovirulent and Hypersusceptible rDNA Hosts
por: Grosjean, Mélanie, et al.
Publicado: (2021)

Engineered resistance and hypersusceptibility through functional metabolic studies of 100 genes in soybean to its major pathogen, the soybean cyst nematode
por: Matthews, Benjamin F., et al.
Publicado: (2013)

Evaluación de la Escala EFD-66 como herramienta para predecir la adherencia al tratamiento en pacientes con enfermedades crónicas no transmisibles
por: Pedroza Cosío, Gabriela Anahí, et al.
Publicado: (2017)

Inhibitors of HIV-1 Reverse Transcriptase—Associated Ribonuclease H Activity
por: Ilina, Tatiana, et al.
Publicado: (2012)

The L76V mutation in HIV-1 protease is potentially associated with hypersusceptibility to protease inhibitors Atazanavir and Saquinavir: is there a clinical advantage?
por: Wiesmann, Frank, et al.
Publicado: (2011)

Mutation of the Enterohemorrhagic Escherichia coli Core LPS Biosynthesis Enzyme RfaD Confers Hypersusceptibility to Host Intestinal Innate Immunity In vivo
por: Kuo, Cheng-Ju, et al.
Publicado: (2016)

Mechanism of Nucleic Acid Unwinding by SARS-CoV Helicase
por: Adedeji, Adeyemi O., et al.
Publicado: (2012)

PRG5 Knockout Precipitates Late-Onset Hypersusceptibility to Pilocarpine-Induced Juvenile Seizures by Exacerbating Hippocampal Zinc Signaling-Mediated Mitochondrial Damage
por: Wang, Dandan, et al.
Publicado: (2021)

Population pharmacokinetics of tenofovir given as either tenofovir disoproxil fumarate or tenofovir alafenamide in an African population
por: Kawuma, Aida N., et al.
Publicado: (2023)

Design, Synthesis, Biochemical, and Antiviral Evaluations of C6 Benzyl and C6 Biarylmethyl Substituted 2-Hydroxylisoquinoline-1,3-diones: Dual Inhibition against HIV Reverse Transcriptase-Associated RNase H and Polymerase with Antiviral Activities
por: Vernekar, Sanjeev Kumar V., et al.
Publicado: (2014)

Structural Implications of Genotypic Variations in HIV-1 Integrase From Diverse Subtypes
por: Rogers, Leonard, et al.
Publicado: (2018)

A Review and Clinical Understanding of Tenofovir: Tenofovir Disoproxil Fumarate versus Tenofovir Alafenamide
por: Wassner, Chanie, et al.
Publicado: (2020)

Proximal tubular renal dysfunction among HIV infected patients on Tenofovir versus Tenofovir sparing regimen in western Kenya
por: Karoney, Mercy Jelagat, et al.
Publicado: (2022)

Tenofovir alafenamide in the treatment of chronic hepatitis B: design, development, and place in therapy
por: Ogawa, Eiichi, et al.
Publicado: (2017)

Ganciclovir–tenofovir interaction leading to tenofovir-induced nephrotoxicity
por: Soanker, Radhika, et al.
Publicado: (2014)

Population pharmacokinetics of tenofovir and tenofovir‐diphosphate in healthy women
por: Burns, Rebecca N., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_gtm9nsuo8hc8kelshoem82j2n7