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Correction: The importance of microglia in the development of the vasculature in the central nervous system

CORRECTION: After the publication of this work [1] it was brought to our attention that citations in the article were not correspondingly numbered in the reference list. To avoid confusion, the article is republished here in its entirety, with the citations referenced correctly. The Publisher and au...

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Detalles Bibliográficos
Autores principales: Arnold, Tom, Betsholtz, Christer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695819/
https://www.ncbi.nlm.nih.gov/pubmed/23809768
http://dx.doi.org/10.1186/2045-824X-5-12
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author Arnold, Tom
Betsholtz, Christer
author_facet Arnold, Tom
Betsholtz, Christer
author_sort Arnold, Tom
collection PubMed
description CORRECTION: After the publication of this work [1] it was brought to our attention that citations in the article were not correspondingly numbered in the reference list. To avoid confusion, the article is republished here in its entirety, with the citations referenced correctly. The Publisher and authors apologize to the readers for the inconvenience caused. ABSTRACT: The body’s vascular system is thought to have developed in order to supply oxygen and nutrients to cells beyond the reach of simple diffusion. Hence, relative hypoxia in the growing central nervous system (CNS) is a major driving force for the ingression and refinement of the complex vascular bed that serves it. However, even before the establishment of this CNS vascular system, CNS-specific macrophages (microglia) migrate into the brain. Recent studies in mice point to the fundamental importance of microglia in shaping CNS vasculature during development, and re-shaping these vessels during pathological insults. In this review, we discuss the origin of CNS microglia and their localization within the brain based on data obtained in mice. We then review evidence supporting a functional role of these microglia in developmental angiogenesis. Although pathologic processes such as CNS ischemia may subvert the developmental functions of microglia/macrophages with significant effects on brain neo-angiogenesis, we have left this topic to other recent reviews [2,3].
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spelling pubmed-36958192013-06-29 Correction: The importance of microglia in the development of the vasculature in the central nervous system Arnold, Tom Betsholtz, Christer Vasc Cell Correction CORRECTION: After the publication of this work [1] it was brought to our attention that citations in the article were not correspondingly numbered in the reference list. To avoid confusion, the article is republished here in its entirety, with the citations referenced correctly. The Publisher and authors apologize to the readers for the inconvenience caused. ABSTRACT: The body’s vascular system is thought to have developed in order to supply oxygen and nutrients to cells beyond the reach of simple diffusion. Hence, relative hypoxia in the growing central nervous system (CNS) is a major driving force for the ingression and refinement of the complex vascular bed that serves it. However, even before the establishment of this CNS vascular system, CNS-specific macrophages (microglia) migrate into the brain. Recent studies in mice point to the fundamental importance of microglia in shaping CNS vasculature during development, and re-shaping these vessels during pathological insults. In this review, we discuss the origin of CNS microglia and their localization within the brain based on data obtained in mice. We then review evidence supporting a functional role of these microglia in developmental angiogenesis. Although pathologic processes such as CNS ischemia may subvert the developmental functions of microglia/macrophages with significant effects on brain neo-angiogenesis, we have left this topic to other recent reviews [2,3]. BioMed Central 2013-06-25 /pmc/articles/PMC3695819/ /pubmed/23809768 http://dx.doi.org/10.1186/2045-824X-5-12 Text en Copyright © 2013 Arnold and Betsholtz; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Correction
Arnold, Tom
Betsholtz, Christer
Correction: The importance of microglia in the development of the vasculature in the central nervous system
title Correction: The importance of microglia in the development of the vasculature in the central nervous system
title_full Correction: The importance of microglia in the development of the vasculature in the central nervous system
title_fullStr Correction: The importance of microglia in the development of the vasculature in the central nervous system
title_full_unstemmed Correction: The importance of microglia in the development of the vasculature in the central nervous system
title_short Correction: The importance of microglia in the development of the vasculature in the central nervous system
title_sort correction: the importance of microglia in the development of the vasculature in the central nervous system
topic Correction
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695819/
https://www.ncbi.nlm.nih.gov/pubmed/23809768
http://dx.doi.org/10.1186/2045-824X-5-12
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