MHC Class II–Alpha Chain Knockout Mice Support Increased Viral Replication That Is Independent of Their Lack of MHC Class II Cell Surface Expression and Associated Immune Function Deficiencies

MHCII molecules are heterodimeric cell surface proteins composed of an α and β chain. These molecules are almost exclusively expressed on thymic epithelium and antigen presenting cells (APCs) and play a central role in the development and function of CD4 T cells. Various MHC-II knockout mice have be...

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Detalles Bibliográficos
Autores principales: Alsharifi, Mohammed, Koskinen, Aulikki, Wijesundara, Danushka K., Bettadapura, Jayaram, Müllbacher, Arno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695910/
https://www.ncbi.nlm.nih.gov/pubmed/23840854
http://dx.doi.org/10.1371/journal.pone.0068458

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