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The Role of PTEN in Chronic Growth Hormone-Induced Hepatic Insulin Resistance

Chronic growth hormone (GH) therapy has been shown to cause insulin resistance, but the mechanism remains unknown. PTEN, a tumor suppressor gene, is a major negative regulator of insulin signaling. In this study, we explored the effect of chronic GH on insulin signaling in the context of PTEN functi...

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Detalles Bibliográficos
Autores principales: Gao, Yuan, Su, Peizhu, Wang, Chuqiong, Zhu, Kongqin, Chen, Xiaolan, Liu, Side, He, Jiman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695944/
https://www.ncbi.nlm.nih.gov/pubmed/23840818
http://dx.doi.org/10.1371/journal.pone.0068105