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The Role of PTEN in Chronic Growth Hormone-Induced Hepatic Insulin Resistance
Chronic growth hormone (GH) therapy has been shown to cause insulin resistance, but the mechanism remains unknown. PTEN, a tumor suppressor gene, is a major negative regulator of insulin signaling. In this study, we explored the effect of chronic GH on insulin signaling in the context of PTEN functi...
Autores principales: | Gao, Yuan, Su, Peizhu, Wang, Chuqiong, Zhu, Kongqin, Chen, Xiaolan, Liu, Side, He, Jiman |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695944/ https://www.ncbi.nlm.nih.gov/pubmed/23840818 http://dx.doi.org/10.1371/journal.pone.0068105 |
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