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Structure and Dynamics of the gp120 V3 Loop That Confers Noncompetitive Resistance in R5 HIV-1(JR-FL) to Maraviroc

Maraviroc, an (HIV-1) entry inhibitor, binds to CCR5 and efficiently prevents R5 human immunodeficiency virus type 1 (HIV-1) from using CCR5 as a coreceptor for entry into CD4(+) cells. However, HIV-1 can elude maraviroc by using the drug-bound form of CCR5 as a coreceptor. This property is known as...

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Detalles Bibliográficos
Autores principales:	Yuan, Yuzhe, Yokoyama, Masaru, Maeda, Yosuke, Terasawa, Hiromi, Harada, Shinji, Sato, Hironori, Yusa, Keisuke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695986/ https://www.ncbi.nlm.nih.gov/pubmed/23840315 http://dx.doi.org/10.1371/journal.pone.0065115

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