RNP2 of RNA Recognition Motif 1 Plays a Central Role in the Aberrant Modification of TDP-43

Phosphorylated and truncated TAR DNA-binding protein-43 (TDP-43) is a major component of ubiquitinated cytoplasmic inclusions in neuronal and glial cells of two TDP-43 proteinopathies, amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Modifications of TDP-43 are thus considered to...

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Detalles Bibliográficos
Autores principales: Takagi, Shinnosuke, Iguchi, Yohei, Katsuno, Masahisa, Ishigaki, Shinsuke, Ikenaka, Kensuke, Fujioka, Yusuke, Honda, Daiyu, Niwa, Jun-ichi, Tanaka, Fumiaki, Watanabe, Hirohisa, Adachi, Hiroaki, Sobue, Gen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695991/
https://www.ncbi.nlm.nih.gov/pubmed/23840565
http://dx.doi.org/10.1371/journal.pone.0066966

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