Cargando…
Stabilization of HIF-2alpha through redox regulation of mTORC2 activation and initiation of mRNA translation
HIF-2alpha plays a critical role in renal tumorigenesis. HIF-2alpha is stabilized in Von Hippel-Lindau (VHL)-deficient renal cell carcinoma through mechanisms that require ongoing mRNA translation. Mammalian target of Rapamycin (mTOR) functions in two distinct complexes, Raptor-associated mTORC1 and...
Autores principales: | Nayak, Bijaya K., Feliers, Denis, Sudarshan, Sunil, Friedrichs, William E., Day, Robert T., New, David D., Fitzgerald, John P., Eid, Assaad, DeNapoli, Thomas, Parekh, Dipen J., Gorin, Yves, Block, Karen |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696051/ https://www.ncbi.nlm.nih.gov/pubmed/22869144 http://dx.doi.org/10.1038/onc.2012.333 |
Ejemplares similares
-
Nox4 Mediates Renal Cell Carcinoma Cell Invasion through Hypoxia-Induced Interleukin 6- and 8- Production
por: Fitzgerald, John P., et al.
Publicado: (2012) -
PI3K regulation of the SKP-2/p27 axis through mTORC2
por: Shanmugasundaram, Karthigayan, et al.
Publicado: (2012) -
mTORC1 and mTORC2 in cancer and the tumor microenvironment
por: Kim, Laura C., et al.
Publicado: (2016) -
Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension
por: Tang, Haiyang, et al.
Publicado: (2018) -
Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion
por: Chen, Long, et al.
Publicado: (2015)