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A2E Induces IL-1ß Production in Retinal Pigment Epithelial Cells via the NLRP3 Inflammasome

AIMS: With ageing extracellular material is deposited in Bruch’s membrane, as drusen. Lipofuscin is deposited in retinal pigment epithelial cells. Both of these changes are associated with age related macular degeneration, a disease now believed to involve chronic inflammation at the retinal-choroid...

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Detalles Bibliográficos
Autores principales:	Anderson, Owen A., Finkelstein, Arthur, Shima, David T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696103/ https://www.ncbi.nlm.nih.gov/pubmed/23840644 http://dx.doi.org/10.1371/journal.pone.0067263

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