Anti-thrombotic activity of DT-13, a saponin isolated from the root tuber of Liriope muscari

OBJECTIVE: To investigate the anti-thrombotic activity of DT-13 in experimental animal models. MATERIALS AND METHODS: The anti-thrombotic activity of DT-13 was evaluated by measuring the thrombus induced by inferior vena cava (IVC) ligation in mice and rats. The anti-thrombotic mechanism of DT-13 wa...

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Detalles Bibliográficos
Autores principales: Tian, Youqing, Ma, Shengtang, Lin, Biqi, Kou, Junping, Yu, Boyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696302/
https://www.ncbi.nlm.nih.gov/pubmed/23833374
http://dx.doi.org/10.4103/0253-7613.111896
Descripción
Sumario:OBJECTIVE: To investigate the anti-thrombotic activity of DT-13 in experimental animal models. MATERIALS AND METHODS: The anti-thrombotic activity of DT-13 was evaluated by measuring the thrombus induced by inferior vena cava (IVC) ligation in mice and rats. The anti-thrombotic mechanism of DT-13 was investigated by assessing the mRNA expression levels of interleukin-6 (IL-6) and tissue factor (TF) in rat IVC tissue around thrombus. RESULTS: DT-13 markedly inhibited thrombosis induced by IVC ligation for 6 h in mice (2.0 and 4.0 mg/kg, p.o.) and for 18 h in rats (1.4 mg/kg, p.o.). Furthermore, DT-13 down-regulated the increased mRNA expression levels of IL-6 and TF in rats. CONCLUSIONS: DT-13 has an anti-thrombotic activity due to down-regulation of the increased mRNA expression levels of IL-6 and TF.

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