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Anti-thrombotic activity of DT-13, a saponin isolated from the root tuber of Liriope muscari

OBJECTIVE: To investigate the anti-thrombotic activity of DT-13 in experimental animal models. MATERIALS AND METHODS: The anti-thrombotic activity of DT-13 was evaluated by measuring the thrombus induced by inferior vena cava (IVC) ligation in mice and rats. The anti-thrombotic mechanism of DT-13 wa...

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Autores principales: Tian, Youqing, Ma, Shengtang, Lin, Biqi, Kou, Junping, Yu, Boyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696302/
https://www.ncbi.nlm.nih.gov/pubmed/23833374
http://dx.doi.org/10.4103/0253-7613.111896
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author Tian, Youqing
Ma, Shengtang
Lin, Biqi
Kou, Junping
Yu, Boyang
author_facet Tian, Youqing
Ma, Shengtang
Lin, Biqi
Kou, Junping
Yu, Boyang
author_sort Tian, Youqing
collection PubMed
description OBJECTIVE: To investigate the anti-thrombotic activity of DT-13 in experimental animal models. MATERIALS AND METHODS: The anti-thrombotic activity of DT-13 was evaluated by measuring the thrombus induced by inferior vena cava (IVC) ligation in mice and rats. The anti-thrombotic mechanism of DT-13 was investigated by assessing the mRNA expression levels of interleukin-6 (IL-6) and tissue factor (TF) in rat IVC tissue around thrombus. RESULTS: DT-13 markedly inhibited thrombosis induced by IVC ligation for 6 h in mice (2.0 and 4.0 mg/kg, p.o.) and for 18 h in rats (1.4 mg/kg, p.o.). Furthermore, DT-13 down-regulated the increased mRNA expression levels of IL-6 and TF in rats. CONCLUSIONS: DT-13 has an anti-thrombotic activity due to down-regulation of the increased mRNA expression levels of IL-6 and TF.
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spelling pubmed-36963022013-07-05 Anti-thrombotic activity of DT-13, a saponin isolated from the root tuber of Liriope muscari Tian, Youqing Ma, Shengtang Lin, Biqi Kou, Junping Yu, Boyang Indian J Pharmacol Short Communication OBJECTIVE: To investigate the anti-thrombotic activity of DT-13 in experimental animal models. MATERIALS AND METHODS: The anti-thrombotic activity of DT-13 was evaluated by measuring the thrombus induced by inferior vena cava (IVC) ligation in mice and rats. The anti-thrombotic mechanism of DT-13 was investigated by assessing the mRNA expression levels of interleukin-6 (IL-6) and tissue factor (TF) in rat IVC tissue around thrombus. RESULTS: DT-13 markedly inhibited thrombosis induced by IVC ligation for 6 h in mice (2.0 and 4.0 mg/kg, p.o.) and for 18 h in rats (1.4 mg/kg, p.o.). Furthermore, DT-13 down-regulated the increased mRNA expression levels of IL-6 and TF in rats. CONCLUSIONS: DT-13 has an anti-thrombotic activity due to down-regulation of the increased mRNA expression levels of IL-6 and TF. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3696302/ /pubmed/23833374 http://dx.doi.org/10.4103/0253-7613.111896 Text en Copyright: © Indian Journal of Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Tian, Youqing
Ma, Shengtang
Lin, Biqi
Kou, Junping
Yu, Boyang
Anti-thrombotic activity of DT-13, a saponin isolated from the root tuber of Liriope muscari
title Anti-thrombotic activity of DT-13, a saponin isolated from the root tuber of Liriope muscari
title_full Anti-thrombotic activity of DT-13, a saponin isolated from the root tuber of Liriope muscari
title_fullStr Anti-thrombotic activity of DT-13, a saponin isolated from the root tuber of Liriope muscari
title_full_unstemmed Anti-thrombotic activity of DT-13, a saponin isolated from the root tuber of Liriope muscari
title_short Anti-thrombotic activity of DT-13, a saponin isolated from the root tuber of Liriope muscari
title_sort anti-thrombotic activity of dt-13, a saponin isolated from the root tuber of liriope muscari
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696302/
https://www.ncbi.nlm.nih.gov/pubmed/23833374
http://dx.doi.org/10.4103/0253-7613.111896
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