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Anti-thrombotic activity of DT-13, a saponin isolated from the root tuber of Liriope muscari
OBJECTIVE: To investigate the anti-thrombotic activity of DT-13 in experimental animal models. MATERIALS AND METHODS: The anti-thrombotic activity of DT-13 was evaluated by measuring the thrombus induced by inferior vena cava (IVC) ligation in mice and rats. The anti-thrombotic mechanism of DT-13 wa...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696302/ https://www.ncbi.nlm.nih.gov/pubmed/23833374 http://dx.doi.org/10.4103/0253-7613.111896 |
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author | Tian, Youqing Ma, Shengtang Lin, Biqi Kou, Junping Yu, Boyang |
author_facet | Tian, Youqing Ma, Shengtang Lin, Biqi Kou, Junping Yu, Boyang |
author_sort | Tian, Youqing |
collection | PubMed |
description | OBJECTIVE: To investigate the anti-thrombotic activity of DT-13 in experimental animal models. MATERIALS AND METHODS: The anti-thrombotic activity of DT-13 was evaluated by measuring the thrombus induced by inferior vena cava (IVC) ligation in mice and rats. The anti-thrombotic mechanism of DT-13 was investigated by assessing the mRNA expression levels of interleukin-6 (IL-6) and tissue factor (TF) in rat IVC tissue around thrombus. RESULTS: DT-13 markedly inhibited thrombosis induced by IVC ligation for 6 h in mice (2.0 and 4.0 mg/kg, p.o.) and for 18 h in rats (1.4 mg/kg, p.o.). Furthermore, DT-13 down-regulated the increased mRNA expression levels of IL-6 and TF in rats. CONCLUSIONS: DT-13 has an anti-thrombotic activity due to down-regulation of the increased mRNA expression levels of IL-6 and TF. |
format | Online Article Text |
id | pubmed-3696302 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-36963022013-07-05 Anti-thrombotic activity of DT-13, a saponin isolated from the root tuber of Liriope muscari Tian, Youqing Ma, Shengtang Lin, Biqi Kou, Junping Yu, Boyang Indian J Pharmacol Short Communication OBJECTIVE: To investigate the anti-thrombotic activity of DT-13 in experimental animal models. MATERIALS AND METHODS: The anti-thrombotic activity of DT-13 was evaluated by measuring the thrombus induced by inferior vena cava (IVC) ligation in mice and rats. The anti-thrombotic mechanism of DT-13 was investigated by assessing the mRNA expression levels of interleukin-6 (IL-6) and tissue factor (TF) in rat IVC tissue around thrombus. RESULTS: DT-13 markedly inhibited thrombosis induced by IVC ligation for 6 h in mice (2.0 and 4.0 mg/kg, p.o.) and for 18 h in rats (1.4 mg/kg, p.o.). Furthermore, DT-13 down-regulated the increased mRNA expression levels of IL-6 and TF in rats. CONCLUSIONS: DT-13 has an anti-thrombotic activity due to down-regulation of the increased mRNA expression levels of IL-6 and TF. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3696302/ /pubmed/23833374 http://dx.doi.org/10.4103/0253-7613.111896 Text en Copyright: © Indian Journal of Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communication Tian, Youqing Ma, Shengtang Lin, Biqi Kou, Junping Yu, Boyang Anti-thrombotic activity of DT-13, a saponin isolated from the root tuber of Liriope muscari |
title | Anti-thrombotic activity of DT-13, a saponin isolated from the root tuber of Liriope muscari |
title_full | Anti-thrombotic activity of DT-13, a saponin isolated from the root tuber of Liriope muscari |
title_fullStr | Anti-thrombotic activity of DT-13, a saponin isolated from the root tuber of Liriope muscari |
title_full_unstemmed | Anti-thrombotic activity of DT-13, a saponin isolated from the root tuber of Liriope muscari |
title_short | Anti-thrombotic activity of DT-13, a saponin isolated from the root tuber of Liriope muscari |
title_sort | anti-thrombotic activity of dt-13, a saponin isolated from the root tuber of liriope muscari |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696302/ https://www.ncbi.nlm.nih.gov/pubmed/23833374 http://dx.doi.org/10.4103/0253-7613.111896 |
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