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Zinc-induced Self-association of Complement C3b and Factor H: IMPLICATIONS FOR INFLAMMATION AND AGE-RELATED MACULAR DEGENERATION

The sub-retinal pigment epithelial deposits that are a hallmark of age-related macular degeneration contain both C3b and millimolar levels of zinc. C3 is the central protein of complement, whereas C3u is formed by the spontaneous hydrolysis of the thioester bridge in C3. During activation, C3 is cle...

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Detalles Bibliográficos
Autores principales:	Nan, Ruodan, Tetchner, Stuart, Rodriguez, Elizabeth, Pao, Po-Jung, Gor, Jayesh, Lengyel, Imre, Perkins, Stephen J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2013
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696691/ https://www.ncbi.nlm.nih.gov/pubmed/23661701 http://dx.doi.org/10.1074/jbc.M113.476143

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