Feline mammary carcinoma stem cells are tumorigenic, radioresistant, chemoresistant and defective in activation of the ATM/p53 DNA damage pathway

Cancer stem cells were identified in a feline mammary carcinoma cell line by demonstrating expression of CD133 and utilising the tumour sphere assay. A population of cells was identified that had an invasive, mesenchymal phenotype, expressed markers of pluripotency and enhanced tumour formation in t...

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Detalles Bibliográficos
Autores principales: Pang, L.Y., Blacking, T.M., Else, R.W., Sherman, A., Sang, H.M., Whitelaw, B.A., Hupp, T.R., Argyle, D.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Balliere Tindall 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696732/
https://www.ncbi.nlm.nih.gov/pubmed/23219486
http://dx.doi.org/10.1016/j.tvjl.2012.10.021
Descripción
Sumario:Cancer stem cells were identified in a feline mammary carcinoma cell line by demonstrating expression of CD133 and utilising the tumour sphere assay. A population of cells was identified that had an invasive, mesenchymal phenotype, expressed markers of pluripotency and enhanced tumour formation in the NOD-SCID mouse and chick embryo models. This population of feline mammary carcinoma stem cells was resistant to chemotherapy and radiation, possibly due to aberrant activation of the ATM/p53 DNA damage pathway. Epithelial–mesenchymal transition was a feature of the invasive phenotype. These data demonstrate that cancer stem cells are a feature of mammary cancer in cats.

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