Feline mammary carcinoma stem cells are tumorigenic, radioresistant, chemoresistant and defective in activation of the ATM/p53 DNA damage pathway

Cancer stem cells were identified in a feline mammary carcinoma cell line by demonstrating expression of CD133 and utilising the tumour sphere assay. A population of cells was identified that had an invasive, mesenchymal phenotype, expressed markers of pluripotency and enhanced tumour formation in t...

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Autores principales: Pang, L.Y., Blacking, T.M., Else, R.W., Sherman, A., Sang, H.M., Whitelaw, B.A., Hupp, T.R., Argyle, D.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Balliere Tindall 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696732/
https://www.ncbi.nlm.nih.gov/pubmed/23219486
http://dx.doi.org/10.1016/j.tvjl.2012.10.021
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author Pang, L.Y.
Blacking, T.M.
Else, R.W.
Sherman, A.
Sang, H.M.
Whitelaw, B.A.
Hupp, T.R.
Argyle, D.J.
author_facet Pang, L.Y.
Blacking, T.M.
Else, R.W.
Sherman, A.
Sang, H.M.
Whitelaw, B.A.
Hupp, T.R.
Argyle, D.J.
author_sort Pang, L.Y.
collection PubMed
description Cancer stem cells were identified in a feline mammary carcinoma cell line by demonstrating expression of CD133 and utilising the tumour sphere assay. A population of cells was identified that had an invasive, mesenchymal phenotype, expressed markers of pluripotency and enhanced tumour formation in the NOD-SCID mouse and chick embryo models. This population of feline mammary carcinoma stem cells was resistant to chemotherapy and radiation, possibly due to aberrant activation of the ATM/p53 DNA damage pathway. Epithelial–mesenchymal transition was a feature of the invasive phenotype. These data demonstrate that cancer stem cells are a feature of mammary cancer in cats.
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spelling pubmed-36967322013-07-01 Feline mammary carcinoma stem cells are tumorigenic, radioresistant, chemoresistant and defective in activation of the ATM/p53 DNA damage pathway Pang, L.Y. Blacking, T.M. Else, R.W. Sherman, A. Sang, H.M. Whitelaw, B.A. Hupp, T.R. Argyle, D.J. Vet J Article Cancer stem cells were identified in a feline mammary carcinoma cell line by demonstrating expression of CD133 and utilising the tumour sphere assay. A population of cells was identified that had an invasive, mesenchymal phenotype, expressed markers of pluripotency and enhanced tumour formation in the NOD-SCID mouse and chick embryo models. This population of feline mammary carcinoma stem cells was resistant to chemotherapy and radiation, possibly due to aberrant activation of the ATM/p53 DNA damage pathway. Epithelial–mesenchymal transition was a feature of the invasive phenotype. These data demonstrate that cancer stem cells are a feature of mammary cancer in cats. Balliere Tindall 2013-06 /pmc/articles/PMC3696732/ /pubmed/23219486 http://dx.doi.org/10.1016/j.tvjl.2012.10.021 Text en © 2013 Elsevier Ltd. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license
spellingShingle Article
Pang, L.Y.
Blacking, T.M.
Else, R.W.
Sherman, A.
Sang, H.M.
Whitelaw, B.A.
Hupp, T.R.
Argyle, D.J.
Feline mammary carcinoma stem cells are tumorigenic, radioresistant, chemoresistant and defective in activation of the ATM/p53 DNA damage pathway
title Feline mammary carcinoma stem cells are tumorigenic, radioresistant, chemoresistant and defective in activation of the ATM/p53 DNA damage pathway
title_full Feline mammary carcinoma stem cells are tumorigenic, radioresistant, chemoresistant and defective in activation of the ATM/p53 DNA damage pathway
title_fullStr Feline mammary carcinoma stem cells are tumorigenic, radioresistant, chemoresistant and defective in activation of the ATM/p53 DNA damage pathway
title_full_unstemmed Feline mammary carcinoma stem cells are tumorigenic, radioresistant, chemoresistant and defective in activation of the ATM/p53 DNA damage pathway
title_short Feline mammary carcinoma stem cells are tumorigenic, radioresistant, chemoresistant and defective in activation of the ATM/p53 DNA damage pathway
title_sort feline mammary carcinoma stem cells are tumorigenic, radioresistant, chemoresistant and defective in activation of the atm/p53 dna damage pathway
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696732/
https://www.ncbi.nlm.nih.gov/pubmed/23219486
http://dx.doi.org/10.1016/j.tvjl.2012.10.021
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