MICE Models: Superior to the HERG Model in Predicting Torsade de Pointes

Drug-induced block of the cardiac hERG (human Ether-à-go-go-Related Gene) potassium channel delays cardiac repolarization and increases the risk of Torsade de Pointes (TdP), a potentially lethal arrhythmia. A positive hERG assay has been embraced by regulators as a non-clinical predictor of TdP desp...

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Detalles Bibliográficos
Autores principales: Kramer, James, Obejero-Paz, Carlos A., Myatt, Glenn, Kuryshev, Yuri A., Bruening-Wright, Andrew, Verducci, Joseph S., Brown, Arthur M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696896/
https://www.ncbi.nlm.nih.gov/pubmed/23812503
http://dx.doi.org/10.1038/srep02100

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