Isolation of new polyketide metabolites, linearolides A and B, from Streptomyces sp. RK95-74

Although all Streptomyces strains are now thought to have 20–30 gene clusters for secondary metabolite biosynthesis, we cannot actually identify so many kinds of metabolites from one strain by conventional methods. Using Streptomyces sp. RK95-74, previously found as a cytotrienin producer, we search...

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Detalles Bibliográficos
Autores principales: Ueki, Masashi, Koshiro, Naofumi, Aono, Harumi, Kawatani, Makoto, Uramoto, Masakazu, Kawasaki, Hisashi, Osada, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696930/
https://www.ncbi.nlm.nih.gov/pubmed/23531987
http://dx.doi.org/10.1038/ja.2013.19
Descripción
Sumario:Although all Streptomyces strains are now thought to have 20–30 gene clusters for secondary metabolite biosynthesis, we cannot actually identify so many kinds of metabolites from one strain by conventional methods. Using Streptomyces sp. RK95-74, previously found as a cytotrienin producer, we searched new metabolites other than cytotrienin derivatives. Following the cultivation with new media and the peak-guided fractionation, we have found new compounds with new polyketide scaffold, named linearolides A and B.

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