Isolation of new polyketide metabolites, linearolides A and B, from Streptomyces sp. RK95-74

Although all Streptomyces strains are now thought to have 20–30 gene clusters for secondary metabolite biosynthesis, we cannot actually identify so many kinds of metabolites from one strain by conventional methods. Using Streptomyces sp. RK95-74, previously found as a cytotrienin producer, we search...

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Autores principales: Ueki, Masashi, Koshiro, Naofumi, Aono, Harumi, Kawatani, Makoto, Uramoto, Masakazu, Kawasaki, Hisashi, Osada, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696930/
https://www.ncbi.nlm.nih.gov/pubmed/23531987
http://dx.doi.org/10.1038/ja.2013.19
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author Ueki, Masashi
Koshiro, Naofumi
Aono, Harumi
Kawatani, Makoto
Uramoto, Masakazu
Kawasaki, Hisashi
Osada, Hiroyuki
author_facet Ueki, Masashi
Koshiro, Naofumi
Aono, Harumi
Kawatani, Makoto
Uramoto, Masakazu
Kawasaki, Hisashi
Osada, Hiroyuki
author_sort Ueki, Masashi
collection PubMed
description Although all Streptomyces strains are now thought to have 20–30 gene clusters for secondary metabolite biosynthesis, we cannot actually identify so many kinds of metabolites from one strain by conventional methods. Using Streptomyces sp. RK95-74, previously found as a cytotrienin producer, we searched new metabolites other than cytotrienin derivatives. Following the cultivation with new media and the peak-guided fractionation, we have found new compounds with new polyketide scaffold, named linearolides A and B.
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spelling pubmed-36969302013-07-01 Isolation of new polyketide metabolites, linearolides A and B, from Streptomyces sp. RK95-74 Ueki, Masashi Koshiro, Naofumi Aono, Harumi Kawatani, Makoto Uramoto, Masakazu Kawasaki, Hisashi Osada, Hiroyuki J Antibiot (Tokyo) Original Article Although all Streptomyces strains are now thought to have 20–30 gene clusters for secondary metabolite biosynthesis, we cannot actually identify so many kinds of metabolites from one strain by conventional methods. Using Streptomyces sp. RK95-74, previously found as a cytotrienin producer, we searched new metabolites other than cytotrienin derivatives. Following the cultivation with new media and the peak-guided fractionation, we have found new compounds with new polyketide scaffold, named linearolides A and B. Nature Publishing Group 2013-06 2013-03-27 /pmc/articles/PMC3696930/ /pubmed/23531987 http://dx.doi.org/10.1038/ja.2013.19 Text en Copyright © 2013 Japan Antibiotics Research Association http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Original Article
Ueki, Masashi
Koshiro, Naofumi
Aono, Harumi
Kawatani, Makoto
Uramoto, Masakazu
Kawasaki, Hisashi
Osada, Hiroyuki
Isolation of new polyketide metabolites, linearolides A and B, from Streptomyces sp. RK95-74
title Isolation of new polyketide metabolites, linearolides A and B, from Streptomyces sp. RK95-74
title_full Isolation of new polyketide metabolites, linearolides A and B, from Streptomyces sp. RK95-74
title_fullStr Isolation of new polyketide metabolites, linearolides A and B, from Streptomyces sp. RK95-74
title_full_unstemmed Isolation of new polyketide metabolites, linearolides A and B, from Streptomyces sp. RK95-74
title_short Isolation of new polyketide metabolites, linearolides A and B, from Streptomyces sp. RK95-74
title_sort isolation of new polyketide metabolites, linearolides a and b, from streptomyces sp. rk95-74
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696930/
https://www.ncbi.nlm.nih.gov/pubmed/23531987
http://dx.doi.org/10.1038/ja.2013.19
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