Evaluation of an In Silico PBPK Post-Bariatric Surgery Model through Simulating Oral Drug Bioavailability of Atorvastatin and Cyclosporine

An increasing prevalence of morbid obesity has led to dramatic increases in the number of bariatric surgeries performed. Altered gastrointestinal physiology following surgery can be associated with modified oral drug bioavailability (F(oral)). In the absence of clinical data, an indication of change...

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Detalles Bibliográficos
Autores principales: Darwich, A S, Pade, D, Rowland-Yeo, K, Jamei, M, Åsberg, A, Christensen, H, Ashcroft, D M, Rostami-Hodjegan, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697036/
https://www.ncbi.nlm.nih.gov/pubmed/23903405
http://dx.doi.org/10.1038/psp.2013.23

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