Modeling and Simulation Workbench for NONMEM: Tutorial on Pirana, PsN, and Xpose

Several software tools are available that facilitate the use of the NONMEM software and extend its functionality. This tutorial shows how three commonly used and freely available tools, Pirana, PsN, and Xpose, form a tightly integrated workbench for modeling and simulation with NONMEM. During the tu...

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Detalles Bibliográficos
Autores principales: Keizer, R J, Karlsson, M O, Hooker, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Tutorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697037/
https://www.ncbi.nlm.nih.gov/pubmed/23836189
http://dx.doi.org/10.1038/psp.2013.24
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author Keizer, R J
Karlsson, M O
Hooker, A
author_facet Keizer, R J
Karlsson, M O
Hooker, A
author_sort Keizer, R J
collection PubMed
description Several software tools are available that facilitate the use of the NONMEM software and extend its functionality. This tutorial shows how three commonly used and freely available tools, Pirana, PsN, and Xpose, form a tightly integrated workbench for modeling and simulation with NONMEM. During the tutorial, we provide some guidance on what diagnostics we consider most useful in pharmacokinetic model development and how to construct them using these tools.
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spelling pubmed-36970372013-07-01 Modeling and Simulation Workbench for NONMEM: Tutorial on Pirana, PsN, and Xpose Keizer, R J Karlsson, M O Hooker, A CPT Pharmacometrics Syst Pharmacol Tutorial Several software tools are available that facilitate the use of the NONMEM software and extend its functionality. This tutorial shows how three commonly used and freely available tools, Pirana, PsN, and Xpose, form a tightly integrated workbench for modeling and simulation with NONMEM. During the tutorial, we provide some guidance on what diagnostics we consider most useful in pharmacokinetic model development and how to construct them using these tools. Nature Publishing Group 2013-06 2013-06-26 /pmc/articles/PMC3697037/ /pubmed/23836189 http://dx.doi.org/10.1038/psp.2013.24 Text en Copyright © 2013 American Society for Clinical Pharmacology and Therapeutics http://creativecommons.org/licenses/by-nc-nd/3.0/ CPT: Pharmacometrics and Systems Pharmacology is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Tutorial
Keizer, R J
Karlsson, M O
Hooker, A
Modeling and Simulation Workbench for NONMEM: Tutorial on Pirana, PsN, and Xpose
title Modeling and Simulation Workbench for NONMEM: Tutorial on Pirana, PsN, and Xpose
title_full Modeling and Simulation Workbench for NONMEM: Tutorial on Pirana, PsN, and Xpose
title_fullStr Modeling and Simulation Workbench for NONMEM: Tutorial on Pirana, PsN, and Xpose
title_full_unstemmed Modeling and Simulation Workbench for NONMEM: Tutorial on Pirana, PsN, and Xpose
title_short Modeling and Simulation Workbench for NONMEM: Tutorial on Pirana, PsN, and Xpose
title_sort modeling and simulation workbench for nonmem: tutorial on pirana, psn, and xpose
topic Tutorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697037/
https://www.ncbi.nlm.nih.gov/pubmed/23836189
http://dx.doi.org/10.1038/psp.2013.24
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