HLA-G/C, miRNAs, and Their Role in HIV Infection and Replication

In recent years, a number of different mechanisms regulating gene expressions, either in normal or in pathological conditions, have been discovered. This review aims to highlight some of the regulatory pathways involved during the HIV-1 infection and disease progression, focusing on the novel discov...

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Detalles Bibliográficos
Autores principales: Celsi, Fulvio, Catamo, Eulalia, Kleiner, Giulio, Tricarico, Paola Maura, Vuch, Josef, Crovella, Sergio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697138/
https://www.ncbi.nlm.nih.gov/pubmed/23841087
http://dx.doi.org/10.1155/2013/693643
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author Celsi, Fulvio
Catamo, Eulalia
Kleiner, Giulio
Tricarico, Paola Maura
Vuch, Josef
Crovella, Sergio
author_facet Celsi, Fulvio
Catamo, Eulalia
Kleiner, Giulio
Tricarico, Paola Maura
Vuch, Josef
Crovella, Sergio
author_sort Celsi, Fulvio
collection PubMed
description In recent years, a number of different mechanisms regulating gene expressions, either in normal or in pathological conditions, have been discovered. This review aims to highlight some of the regulatory pathways involved during the HIV-1 infection and disease progression, focusing on the novel discovered microRNAs (miRNAs) and their relation with immune system's agents. Human leukocyte antigen (HLA) family of proteins plays a key role because it is a crucial modulator of the immune response; here we will examine recent findings, centering especially on HLA-C and -G, novel players lately discovered to engage in modulation of immune system. We hope to provide novel perspectives useful to find out original therapeutic roads against HIV-1 infection and AIDS progression.
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spelling pubmed-36971382013-07-09 HLA-G/C, miRNAs, and Their Role in HIV Infection and Replication Celsi, Fulvio Catamo, Eulalia Kleiner, Giulio Tricarico, Paola Maura Vuch, Josef Crovella, Sergio Biomed Res Int Review Article In recent years, a number of different mechanisms regulating gene expressions, either in normal or in pathological conditions, have been discovered. This review aims to highlight some of the regulatory pathways involved during the HIV-1 infection and disease progression, focusing on the novel discovered microRNAs (miRNAs) and their relation with immune system's agents. Human leukocyte antigen (HLA) family of proteins plays a key role because it is a crucial modulator of the immune response; here we will examine recent findings, centering especially on HLA-C and -G, novel players lately discovered to engage in modulation of immune system. We hope to provide novel perspectives useful to find out original therapeutic roads against HIV-1 infection and AIDS progression. Hindawi Publishing Corporation 2013 2013-06-13 /pmc/articles/PMC3697138/ /pubmed/23841087 http://dx.doi.org/10.1155/2013/693643 Text en Copyright © 2013 Fulvio Celsi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Celsi, Fulvio
Catamo, Eulalia
Kleiner, Giulio
Tricarico, Paola Maura
Vuch, Josef
Crovella, Sergio
HLA-G/C, miRNAs, and Their Role in HIV Infection and Replication
title HLA-G/C, miRNAs, and Their Role in HIV Infection and Replication
title_full HLA-G/C, miRNAs, and Their Role in HIV Infection and Replication
title_fullStr HLA-G/C, miRNAs, and Their Role in HIV Infection and Replication
title_full_unstemmed HLA-G/C, miRNAs, and Their Role in HIV Infection and Replication
title_short HLA-G/C, miRNAs, and Their Role in HIV Infection and Replication
title_sort hla-g/c, mirnas, and their role in hiv infection and replication
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697138/
https://www.ncbi.nlm.nih.gov/pubmed/23841087
http://dx.doi.org/10.1155/2013/693643
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