Evaluating sex hormone levels in reproductive age women with multiple sclerosis and their relationship with disease severity

BACKGROUND: Sex-related differences in the severity of multiple sclerosis (MS) could be influenced by the sex hormones. MATERIALS AND METHODS: This cohort (historical) study evaluated the sex hormone levels during menstrual cycle and their correlation with disease severity in MS. RESULT: Patients wi...

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Autores principales: Foroughipour, Azam, Norbakhsh, Vajihe, Najafabadi, Sara Hosseinpour, Meamar, Rokhsareh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Short Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697216/
https://www.ncbi.nlm.nih.gov/pubmed/23826018
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author Foroughipour, Azam
Norbakhsh, Vajihe
Najafabadi, Sara Hosseinpour
Meamar, Rokhsareh
author_facet Foroughipour, Azam
Norbakhsh, Vajihe
Najafabadi, Sara Hosseinpour
Meamar, Rokhsareh
author_sort Foroughipour, Azam
collection PubMed
description BACKGROUND: Sex-related differences in the severity of multiple sclerosis (MS) could be influenced by the sex hormones. MATERIALS AND METHODS: This cohort (historical) study evaluated the sex hormone levels during menstrual cycle and their correlation with disease severity in MS. RESULT: Patients with MS had significantly lower testosterone, dehydroepiandrosterone sulfate and prolactin levels than controls in the follicular and luteal phase but lower estradiol levels only in the follicular phase. A positive correlation coefficient between follicle stimulating hormone and disease severity, and a reverse correlation with estradiol were found. CONCLUSION: The hormone-related modulation of disease severity supports the suggestion that sex hormones play a role in MS disease.
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spelling pubmed-36972162013-07-03 Evaluating sex hormone levels in reproductive age women with multiple sclerosis and their relationship with disease severity Foroughipour, Azam Norbakhsh, Vajihe Najafabadi, Sara Hosseinpour Meamar, Rokhsareh J Res Med Sci Short Communications BACKGROUND: Sex-related differences in the severity of multiple sclerosis (MS) could be influenced by the sex hormones. MATERIALS AND METHODS: This cohort (historical) study evaluated the sex hormone levels during menstrual cycle and their correlation with disease severity in MS. RESULT: Patients with MS had significantly lower testosterone, dehydroepiandrosterone sulfate and prolactin levels than controls in the follicular and luteal phase but lower estradiol levels only in the follicular phase. A positive correlation coefficient between follicle stimulating hormone and disease severity, and a reverse correlation with estradiol were found. CONCLUSION: The hormone-related modulation of disease severity supports the suggestion that sex hormones play a role in MS disease. Medknow Publications & Media Pvt Ltd 2012-09 /pmc/articles/PMC3697216/ /pubmed/23826018 Text en Copyright: © Journal of Research in Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communications
Foroughipour, Azam
Norbakhsh, Vajihe
Najafabadi, Sara Hosseinpour
Meamar, Rokhsareh
Evaluating sex hormone levels in reproductive age women with multiple sclerosis and their relationship with disease severity
title Evaluating sex hormone levels in reproductive age women with multiple sclerosis and their relationship with disease severity
title_full Evaluating sex hormone levels in reproductive age women with multiple sclerosis and their relationship with disease severity
title_fullStr Evaluating sex hormone levels in reproductive age women with multiple sclerosis and their relationship with disease severity
title_full_unstemmed Evaluating sex hormone levels in reproductive age women with multiple sclerosis and their relationship with disease severity
title_short Evaluating sex hormone levels in reproductive age women with multiple sclerosis and their relationship with disease severity
title_sort evaluating sex hormone levels in reproductive age women with multiple sclerosis and their relationship with disease severity
topic Short Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697216/
https://www.ncbi.nlm.nih.gov/pubmed/23826018
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