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Successful Treatment in a Child with Anaplastic Large Cell Lymphoma and Coexistence of Pulmonary Tuberculosis

A 13-year-old girl was admitted to our department with a history of severe pain of her left axilla and fever. On physical examination, a block of lymph nodes in her left axilla, diffuse papular rash, and red-violet swelling of her supraclavicular and subclavian region were noted. Imaging investigati...

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Autores principales: Baka, Margarita, Doganis, Dimitrios, Pourtsidis, Apostolos, Tsolia, Maria, Bouhoutsou, Despina, Varvoutsi, Maria, Strantzia, Katerina, Kosmidis, Helen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697236/
https://www.ncbi.nlm.nih.gov/pubmed/23841007
http://dx.doi.org/10.1155/2013/928701
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author Baka, Margarita
Doganis, Dimitrios
Pourtsidis, Apostolos
Tsolia, Maria
Bouhoutsou, Despina
Varvoutsi, Maria
Strantzia, Katerina
Kosmidis, Helen
author_facet Baka, Margarita
Doganis, Dimitrios
Pourtsidis, Apostolos
Tsolia, Maria
Bouhoutsou, Despina
Varvoutsi, Maria
Strantzia, Katerina
Kosmidis, Helen
author_sort Baka, Margarita
collection PubMed
description A 13-year-old girl was admitted to our department with a history of severe pain of her left axilla and fever. On physical examination, a block of lymph nodes in her left axilla, diffuse papular rash, and red-violet swelling of her supraclavicular and subclavian region were noted. Imaging investigations revealed left axillar and supraclavicular lymphadenopathy and a small nodular shade in the upper lobe of her left lung. A biopsy from an axillary lymph node established the diagnosis of anaplastic large cell lymphoma (ALCL), whereas DNA of Mycobacterium tuberculosis was detected by polymerase chain reaction (PCR) in the same tissue biopsy. Patient was started on chemotherapy for ALCL and achieved remission of all initially involved fields. Nevertheless, two new nodular lesions were detected in the left lower lobe. Biopsy revealed granulomas, and PCR was positive for M. tuberculosis. Our patient received treatment with the combination of isoniazid and rifampin (12 months), pyrazinamide (the first 2 months), and maintenance chemotherapy for her ALCL for one year simultaneously. Four years later, she is disease free for both mycobacterial infection and lymphoma. We are reporting this successful management of mycobacterial infection in a patient with ALCL despite intensive chemotherapy that the patient received at the same time.
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spelling pubmed-36972362013-07-09 Successful Treatment in a Child with Anaplastic Large Cell Lymphoma and Coexistence of Pulmonary Tuberculosis Baka, Margarita Doganis, Dimitrios Pourtsidis, Apostolos Tsolia, Maria Bouhoutsou, Despina Varvoutsi, Maria Strantzia, Katerina Kosmidis, Helen Case Rep Pediatr Case Report A 13-year-old girl was admitted to our department with a history of severe pain of her left axilla and fever. On physical examination, a block of lymph nodes in her left axilla, diffuse papular rash, and red-violet swelling of her supraclavicular and subclavian region were noted. Imaging investigations revealed left axillar and supraclavicular lymphadenopathy and a small nodular shade in the upper lobe of her left lung. A biopsy from an axillary lymph node established the diagnosis of anaplastic large cell lymphoma (ALCL), whereas DNA of Mycobacterium tuberculosis was detected by polymerase chain reaction (PCR) in the same tissue biopsy. Patient was started on chemotherapy for ALCL and achieved remission of all initially involved fields. Nevertheless, two new nodular lesions were detected in the left lower lobe. Biopsy revealed granulomas, and PCR was positive for M. tuberculosis. Our patient received treatment with the combination of isoniazid and rifampin (12 months), pyrazinamide (the first 2 months), and maintenance chemotherapy for her ALCL for one year simultaneously. Four years later, she is disease free for both mycobacterial infection and lymphoma. We are reporting this successful management of mycobacterial infection in a patient with ALCL despite intensive chemotherapy that the patient received at the same time. Hindawi Publishing Corporation 2013 2013-06-13 /pmc/articles/PMC3697236/ /pubmed/23841007 http://dx.doi.org/10.1155/2013/928701 Text en Copyright © 2013 Margarita Baka et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Baka, Margarita
Doganis, Dimitrios
Pourtsidis, Apostolos
Tsolia, Maria
Bouhoutsou, Despina
Varvoutsi, Maria
Strantzia, Katerina
Kosmidis, Helen
Successful Treatment in a Child with Anaplastic Large Cell Lymphoma and Coexistence of Pulmonary Tuberculosis
title Successful Treatment in a Child with Anaplastic Large Cell Lymphoma and Coexistence of Pulmonary Tuberculosis
title_full Successful Treatment in a Child with Anaplastic Large Cell Lymphoma and Coexistence of Pulmonary Tuberculosis
title_fullStr Successful Treatment in a Child with Anaplastic Large Cell Lymphoma and Coexistence of Pulmonary Tuberculosis
title_full_unstemmed Successful Treatment in a Child with Anaplastic Large Cell Lymphoma and Coexistence of Pulmonary Tuberculosis
title_short Successful Treatment in a Child with Anaplastic Large Cell Lymphoma and Coexistence of Pulmonary Tuberculosis
title_sort successful treatment in a child with anaplastic large cell lymphoma and coexistence of pulmonary tuberculosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697236/
https://www.ncbi.nlm.nih.gov/pubmed/23841007
http://dx.doi.org/10.1155/2013/928701
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