Mutations in panD encoding aspartate decarboxylase are associated with pyrazinamide resistance in Mycobacterium tuberculosis

Pyrazinamide (PZA) is a frontline anti-tuberculosis drug that plays a crucial role in the treatment of both drug susceptible and multidrug-resistant tuberculosis (MDR-TB). Resistance to PZA is most commonly associated with mutations in the pncA gene encoding nicotinamidase/pyrazinamidase which conve...

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Detalles Bibliográficos
Autores principales: Zhang, Shuo, Chen, Jiazhen, Shi, Wanliang, Liu, Wei, Zhang, Wenhong, Zhang, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697303/
https://www.ncbi.nlm.nih.gov/pubmed/26038471
http://dx.doi.org/10.1038/emi.2013.38

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