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A novel onco-miR-365 induces cutaneous squamous cell carcinoma
The expression levels of miR-365 vary in different malignancies. Herein, we found that miR-365 was overexpressed in both cells and clinical specimens of cutaneous squamous cell carcinoma (SCC). We demonstrated that the HaCaT(pre-miR-365-2) cell line, which overexpressed miR-365, could induce subcuta...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697891/ https://www.ncbi.nlm.nih.gov/pubmed/23514750 http://dx.doi.org/10.1093/carcin/bgt097 |
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author | Zhou, Meijuan Liu, Weilin Ma, Shudong Cao, Hong Peng, Xuebiao Guo, Ling Zhou, Xinhua Zheng, Li Guo, Linlang Wan, Miaojian Shi, Weimin He, Yingjie Lu, Chao Jiang, Lihong Ou, Chengshan Guo, Yuanxia Ding, Zhenhua |
author_facet | Zhou, Meijuan Liu, Weilin Ma, Shudong Cao, Hong Peng, Xuebiao Guo, Ling Zhou, Xinhua Zheng, Li Guo, Linlang Wan, Miaojian Shi, Weimin He, Yingjie Lu, Chao Jiang, Lihong Ou, Chengshan Guo, Yuanxia Ding, Zhenhua |
author_sort | Zhou, Meijuan |
collection | PubMed |
description | The expression levels of miR-365 vary in different malignancies. Herein, we found that miR-365 was overexpressed in both cells and clinical specimens of cutaneous squamous cell carcinoma (SCC). We demonstrated that the HaCaT(pre-miR-365-2) cell line, which overexpressed miR-365, could induce subcutaneous tumors in vivo. Antagomir-365, an anti-miR-365 oligonucleotide, inhibited cutaneous tumor formation in vivo, along with G(1) phase arrest and apoptosis of cancer cells. These findings suggest that miR-365 may act as an onco-miR in cutaneous SCC both in vitro and in vivo. The present study provides valuable insight into the role of miR-365 in cutaneous SCC formation, which can help develop new drug and miR-365 target-based therapies for cutaneous SCC. |
format | Online Article Text |
id | pubmed-3697891 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-36978912014-01-13 A novel onco-miR-365 induces cutaneous squamous cell carcinoma Zhou, Meijuan Liu, Weilin Ma, Shudong Cao, Hong Peng, Xuebiao Guo, Ling Zhou, Xinhua Zheng, Li Guo, Linlang Wan, Miaojian Shi, Weimin He, Yingjie Lu, Chao Jiang, Lihong Ou, Chengshan Guo, Yuanxia Ding, Zhenhua Carcinogenesis Original Manuscript The expression levels of miR-365 vary in different malignancies. Herein, we found that miR-365 was overexpressed in both cells and clinical specimens of cutaneous squamous cell carcinoma (SCC). We demonstrated that the HaCaT(pre-miR-365-2) cell line, which overexpressed miR-365, could induce subcutaneous tumors in vivo. Antagomir-365, an anti-miR-365 oligonucleotide, inhibited cutaneous tumor formation in vivo, along with G(1) phase arrest and apoptosis of cancer cells. These findings suggest that miR-365 may act as an onco-miR in cutaneous SCC both in vitro and in vivo. The present study provides valuable insight into the role of miR-365 in cutaneous SCC formation, which can help develop new drug and miR-365 target-based therapies for cutaneous SCC. Oxford University Press 2013-07 2013-03-20 /pmc/articles/PMC3697891/ /pubmed/23514750 http://dx.doi.org/10.1093/carcin/bgt097 Text en © The Author 2013. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Original Manuscript Zhou, Meijuan Liu, Weilin Ma, Shudong Cao, Hong Peng, Xuebiao Guo, Ling Zhou, Xinhua Zheng, Li Guo, Linlang Wan, Miaojian Shi, Weimin He, Yingjie Lu, Chao Jiang, Lihong Ou, Chengshan Guo, Yuanxia Ding, Zhenhua A novel onco-miR-365 induces cutaneous squamous cell carcinoma |
title | A novel onco-miR-365 induces cutaneous squamous cell carcinoma |
title_full | A novel onco-miR-365 induces cutaneous squamous cell carcinoma |
title_fullStr | A novel onco-miR-365 induces cutaneous squamous cell carcinoma |
title_full_unstemmed | A novel onco-miR-365 induces cutaneous squamous cell carcinoma |
title_short | A novel onco-miR-365 induces cutaneous squamous cell carcinoma |
title_sort | novel onco-mir-365 induces cutaneous squamous cell carcinoma |
topic | Original Manuscript |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697891/ https://www.ncbi.nlm.nih.gov/pubmed/23514750 http://dx.doi.org/10.1093/carcin/bgt097 |
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