Gonadotropin-releasing hormone type II (GnRH-II) agonist regulates the invasiveness of endometrial cancer cells through the GnRH-I receptor and mitogen-activated protein kinase (MAPK)-dependent activation of matrix metalloproteinase (MMP)-2

BACKGROUND: More than 25% of patients diagnosed with endometrial carcinoma have an invasive primary cancer accompanied by metastases. Gonadotropin-releasing hormone (GnRH) plays an important role in reproduction. In mammals, expression of GnRH-II is higher than GnRH-I in reproductive tissues. Here,...

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Detalles Bibliográficos
Autores principales: Wu, Hsien-Ming, Wang, Hsin-Shih, Huang, Hong-Yuan, Lai, Chyong-Huey, Lee, Chyi-Long, Soong, Yung-Kuei, Leung, Peter CK
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697993/
https://www.ncbi.nlm.nih.gov/pubmed/23786715
http://dx.doi.org/10.1186/1471-2407-13-300

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