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Plasma in the PICU: why and when should we transfuse?
Whereas red blood cell transfusions have been used since the 19th century, plasma has only been available since 1941. It was originally mainly used as volume replacement, mostly during World War II and the Korean War. Over the years, its indication has shifted to correct coagulation factors deficien...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698065/ https://www.ncbi.nlm.nih.gov/pubmed/23725411 http://dx.doi.org/10.1186/2110-5820-3-16 |
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author | Labarinas, Sonia Arni, Delphine Karam, Oliver |
author_facet | Labarinas, Sonia Arni, Delphine Karam, Oliver |
author_sort | Labarinas, Sonia |
collection | PubMed |
description | Whereas red blood cell transfusions have been used since the 19th century, plasma has only been available since 1941. It was originally mainly used as volume replacement, mostly during World War II and the Korean War. Over the years, its indication has shifted to correct coagulation factors deficiencies or to prevent bleeding. Currently, it remains a frequent treatment in the intensive care unit, both for critically ill adults and children. However, observational studies have shown that plasma transfusion fail to correct mildly abnormal coagulation tests. Furthermore, recent epidemiological studies have shown that plasma transfusions are associated with an increased morbidity and mortality in critically ill patients. Therefore, plasma, as any other treatment, has to be used when the benefits outweigh the risks. Based on observational data, most experts suggest limiting its use either to massively bleeding patients or bleeding patients who have documented abnormal coagulation tests, and refraining for transfusing plasma to nonbleeding patients whatever their coagulation tests. In this paper, we will review current evidence on plasma transfusions and discuss its indications. |
format | Online Article Text |
id | pubmed-3698065 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Springer |
record_format | MEDLINE/PubMed |
spelling | pubmed-36980652013-07-02 Plasma in the PICU: why and when should we transfuse? Labarinas, Sonia Arni, Delphine Karam, Oliver Ann Intensive Care Review Whereas red blood cell transfusions have been used since the 19th century, plasma has only been available since 1941. It was originally mainly used as volume replacement, mostly during World War II and the Korean War. Over the years, its indication has shifted to correct coagulation factors deficiencies or to prevent bleeding. Currently, it remains a frequent treatment in the intensive care unit, both for critically ill adults and children. However, observational studies have shown that plasma transfusion fail to correct mildly abnormal coagulation tests. Furthermore, recent epidemiological studies have shown that plasma transfusions are associated with an increased morbidity and mortality in critically ill patients. Therefore, plasma, as any other treatment, has to be used when the benefits outweigh the risks. Based on observational data, most experts suggest limiting its use either to massively bleeding patients or bleeding patients who have documented abnormal coagulation tests, and refraining for transfusing plasma to nonbleeding patients whatever their coagulation tests. In this paper, we will review current evidence on plasma transfusions and discuss its indications. Springer 2013-06-02 /pmc/articles/PMC3698065/ /pubmed/23725411 http://dx.doi.org/10.1186/2110-5820-3-16 Text en Copyright ©2013 Labarinas et al.; licensee Springer. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Labarinas, Sonia Arni, Delphine Karam, Oliver Plasma in the PICU: why and when should we transfuse? |
title | Plasma in the PICU: why and when should we transfuse? |
title_full | Plasma in the PICU: why and when should we transfuse? |
title_fullStr | Plasma in the PICU: why and when should we transfuse? |
title_full_unstemmed | Plasma in the PICU: why and when should we transfuse? |
title_short | Plasma in the PICU: why and when should we transfuse? |
title_sort | plasma in the picu: why and when should we transfuse? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698065/ https://www.ncbi.nlm.nih.gov/pubmed/23725411 http://dx.doi.org/10.1186/2110-5820-3-16 |
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