Cargando…

Similarly Potent Inhibition of Adenylyl Cyclase by P-Site Inhibitors in Hearts from Wild Type and AC5 Knockout Mice

Adenylyl cyclase type 5 (AC5) was described as major cardiac AC isoform. The knockout of AC5 (AC5KO) exerted cardioprotective effects in heart failure. Our study explored the impact of AC5KO on mouse heart AC activities and evaluated putative AC5-selective inhibitors. In cardiac membranes from AC5KO...

Descripción completa

Detalles Bibliográficos
Autores principales:	Braeunig, Joerg H., Schweda, Frank, Han, Pyung-Lim, Seifert, Roland
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698094/ https://www.ncbi.nlm.nih.gov/pubmed/23840883 http://dx.doi.org/10.1371/journal.pone.0068009

Ejemplares similares

Effects of 39 Compounds on Calmodulin-Regulated Adenylyl Cyclases AC1 and Bacillus anthracis Edema Factor
por: Lübker, Carolin, et al.
Publicado: (2015)

Calcium activated adenylyl cyclase AC8 but not AC1 is required for prolonged behavioral anxiety
por: Bernabucci, Matteo, et al.
Publicado: (2016)

Function of Adenylyl Cyclase in Heart: the AKAP Connection
por: Baldwin, Tanya A., et al.
Publicado: (2018)

pH sensing via bicarbonate-regulated “soluble” adenylyl cyclase (sAC)
por: Rahman, Nawreen, et al.
Publicado: (2013)

2321: Soluble adenylyl cyclase (sAC) regulates melanogenesis and melanocyte response to UVB
por: Ota, Koji, et al.
Publicado: (2018)

35336 Effect of Nuclear Soluble Adenylyl Cyclase (sAC) on Melanoma Treatment Response
por: Bang, Jakyung, et al.
Publicado: (2021)

Gene Expression Profiles of Main Olfactory Epithelium in Adenylyl Cyclase 3 Knockout Mice
por: Wang, Zhenshan, et al.
Publicado: (2015)

Nucleotidyl Cyclase Activity of Particulate Guanylyl Cyclase A: Comparison with Particulate Guanylyl Cyclases E and F, Soluble Guanylyl Cyclase and Bacterial Adenylyl Cyclases Cyaa and Edema Factor
por: Beste, Kerstin Y., et al.
Publicado: (2013)

New Perspectives on Plant Adenylyl Cyclases
por: Ruzvidzo, Oziniel, et al.
Publicado: (2019)

Expression and functions of adenylyl cyclases in the CNS
por: Devasani, Karan, et al.
Publicado: (2022)

Altered collecting duct adenylyl cyclase content in collecting duct endothelin-1 knockout mice
por: Strait, Kevin A, et al.
Publicado: (2007)

Comparative Phosphoproteomic Profiling of Type III Adenylyl Cyclase Knockout and Control, Male, and Female Mice
por: Zhou, Yuxin, et al.
Publicado: (2019)

Insights into the residence in lipid rafts of adenylyl cyclase AC8 and its regulation by capacitative calcium entry
por: Pagano, Mario, et al.
Publicado: (2009)

Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential
por: Rossetti, Thomas, et al.
Publicado: (2022)

Fine Tuning Adenylyl Cyclase as a (Gene) Therapy for Heart Failure
por: Port, J. David, et al.
Publicado: (2016)

Structural basis of adenylyl cyclase 9 activation
por: Qi, Chao, et al.
Publicado: (2022)

Constitutive inhibitory G protein activity upon adenylyl cyclase-dependent cardiac contractility is limited to adenylyl cyclase type 6
por: Bull Melsom, Caroline, et al.
Publicado: (2019)

Calcium-stimulated adenylyl cyclase subtype 1 (AC1) contributes to LTP in the insular cortex of adult mice
por: Yamanaka, Manabu, et al.
Publicado: (2017)

Adenylyl Cyclase (AC) Mediates the Antidepressant-Like Effects of Tropisetron on a Mouse Model of Maternal Separation Stress
por: Hosseinzadeh, Ali, et al.
Publicado: (2021)

Erratum: Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential
por: Frontiers Production Office,
Publicado: (2022)

Corrigendum: Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential
por: Rossetti, Thomas, et al.
Publicado: (2023)

Adenylyl Cyclase Signaling in the Developing Chick Heart: The Deranging Effect of Antiarrhythmic Drugs
por: Hejnova, Lucie, et al.
Publicado: (2014)

Activation of adenylyl cyclase in Chlamydomonas reinhardtii by adhesion and by heat
Publicado: (1993)

Soluble adenylyl cyclase is essential for proper lysosomal acidification
por: Rahman, Nawreen, et al.
Publicado: (2016)

Editorial: Adenylyl cyclase isoforms as potential drug targets
por: Brust, Tarsis F., et al.
Publicado: (2022)

Evaluation of calcium-sensitive adenylyl cyclase AC1 and AC8 mRNA expression in the anterior cingulate cortex of mice with spared nerve injury neuropathy
por: Shiers, Stephanie, et al.
Publicado: (2021)

POPDC1 scaffolds a complex of adenylyl cyclase 9 and the potassium channel TREK‐1 in heart
por: Baldwin, Tanya A, et al.
Publicado: (2022)

Inhibition of calcium-stimulated adenylyl cyclase subtype 1 (AC1) for the treatment of neuropathic and inflammatory pain in adult female mice
por: Zhou, Zhaoxiang, et al.
Publicado: (2021)

Adenylyl cyclase-5 in the dorsal striatum function as a molecular switch for the generation of behavioral preferences for cue-directed food choices
por: Kim, Hannah, et al.
Publicado: (2014)

Adult Type 3 Adenylyl Cyclase–Deficient Mice Are Obese
por: Wang, Zhenshan, et al.
Publicado: (2009)

Spatial resolution of cAMP signaling by soluble adenylyl cyclase
por: Caldieri, Giusi, et al.
Publicado: (2016)

Adenylyl Cyclase 6 Mediates Inhibition of TNF in the Inflammatory Reflex
por: Tarnawski, Laura, et al.
Publicado: (2018)

Prognosis and regulation of an adenylyl cyclase network in acute myeloid leukemia
por: Chen, Si-Liang, et al.
Publicado: (2020)

The evolutionary conservation of eukaryotic membrane-bound adenylyl cyclase isoforms
por: Schultz, Joachim E.
Publicado: (2022)

Gα(s), adenylyl cyclase, and their relationship to the diagnosis and treatment of depression
por: Schappi, Jeffrey M., et al.
Publicado: (2022)

Characterization of Adenylyl Cyclase Isoform 6 Residues Interacting with Forskolin
por: Bhatia, Vikram, et al.
Publicado: (2023)

Isoform Specific Regulation of Adenylyl Cyclase 5 by Gβγ
por: Yen, Yu-Chen, et al.
Publicado: (2023)

Somatic ‘Soluble’ Adenylyl Cyclase Isoforms Are Unaffected in Sacy(tm1Lex)/Sacy(tm1Lex) ‘Knockout’ Mice
por: Farrell, Jeanne, et al.
Publicado: (2008)

Stimulation of Mammalian G-protein-responsive Adenylyl Cyclases by Carbon Dioxide
por: Townsend, Philip D., et al.
Publicado: (2009)

Sex-Specific Role for Adenylyl Cyclase Type 7 in Alcohol Dependence
por: Desrivières, Sylvane, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_9euj1hm3bu9s35h9g9u8u02c26