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Similarly Potent Inhibition of Adenylyl Cyclase by P-Site Inhibitors in Hearts from Wild Type and AC5 Knockout Mice

Adenylyl cyclase type 5 (AC5) was described as major cardiac AC isoform. The knockout of AC5 (AC5KO) exerted cardioprotective effects in heart failure. Our study explored the impact of AC5KO on mouse heart AC activities and evaluated putative AC5-selective inhibitors. In cardiac membranes from AC5KO...

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Detalles Bibliográficos
Autores principales:	Braeunig, Joerg H., Schweda, Frank, Han, Pyung-Lim, Seifert, Roland
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698094/ https://www.ncbi.nlm.nih.gov/pubmed/23840883 http://dx.doi.org/10.1371/journal.pone.0068009

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