Interferon-α (IFN-α) suppresses HTLV-1 gene expression and cell cycling, while IFN-α combined with zidovudin induces p53 signaling and apoptosis in HTLV-1-infected cells

BACKGROUND: Human T-cell leukemia virus type-1 (HTLV-1) is the causative retrovirus of adult T-cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-1 gene expression is maintained at low levels in vivo by unknown mechanisms. A combination therapy...

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Detalles Bibliográficos
Autores principales: Kinpara, Shuichi, Kijiyama, Mami, Takamori, Ayako, Hasegawa, Atsuhiko, Sasada, Amane, Masuda, Takao, Tanaka, Yuetsu, Utsunomiya, Atae, Kannagi, Mari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698133/
https://www.ncbi.nlm.nih.gov/pubmed/23688327
http://dx.doi.org/10.1186/1742-4690-10-52

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