Cargando…

Functional Comparison of Human Adenomatous Polyposis Coli (APC) and APC-Like in Targeting Beta-Catenin for Degradation

Truncating mutations affect the adenomatous polyposis coli (APC) gene in most cases of colon cancer, resulting in the stabilization of β-catenin and uncontrolled cell proliferation. We show here that colon cancer cell lines express also the paralog APC-like (APCL or APC2). RNA interference revealed...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schneikert, Jean, Vijaya Chandra, Shree Harsha, Ruppert, Jan Gustav, Ray, Suparna, Wenzel, Eva Maria, Behrens, Jürgen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698177/ https://www.ncbi.nlm.nih.gov/pubmed/23840886 http://dx.doi.org/10.1371/journal.pone.0068072

Ejemplares similares

A Common Role for Various Human Truncated Adenomatous Polyposis Coli Isoforms in the Control of Beta-Catenin Activity and Cell Proliferation
por: Vijaya Chandra, Shree Harsha, et al.
Publicado: (2012)

Different Roles for the Axin Interactions with the SAMP versus the Second Twenty Amino Acid Repeat of Adenomatous Polyposis Coli
por: Schneikert, Jean, et al.
Publicado: (2014)

Immunopurification of adenomatous polyposis coli (APC) proteins
por: Elliott, Kerryn L, et al.
Publicado: (2013)

The clinical significance of adenomatous polyposis coli (APC) and catenin Beta 1 (CTNNB1) genetic aberrations in patients with melanoma
por: Karachaliou, Georgia Sofia, et al.
Publicado: (2022)

Adenomatous Polyposis Coli (APC) Is Required for Normal Development of Skin and Thymus
por: Kuraguchi, Mari, et al.
Publicado: (2006)

APC gene mutations and colorectal adenomatosis in familial adenomatous polyposis
por: Ficari, F, et al.
Publicado: (2000)

Attenuated familial adenomatous polyposis with desmoids caused by an APC mutation
por: Ikenoue, Tsuneo, et al.
Publicado: (2015)

Pathogenic APC Variants in Latvian Familial Adenomatous Polyposis Patients
por: Daneberga, Zanda, et al.
Publicado: (2019)

Wild-type APC Influences the Severity of Familial Adenomatous Polyposis
por: Flisikowski, Krzysztof, et al.
Publicado: (2021)

A novel large germ line deletion in adenomatous polyposis coli (APC) gene associated with familial adenomatous polyposis
por: Pouya, Farzaneh, et al.
Publicado: (2018)

Adenomatous polyposis coli (APC) gene promoter hypermethylation in primary breast cancers
por: Jin, Z, et al.
Publicado: (2001)

Mutations of adenomatous polyposis coli (APC) gene are uncommon in sporadic desmoid tumours.
por: Giarola, M., et al.
Publicado: (1998)

Analysing the mutational status of adenomatous polyposis coli (APC) gene in breast cancer
por: Chang, Ya-Sian, et al.
Publicado: (2016)

Contribution of APC and MUTYH mutations to familial adenomatous polyposis susceptibility in Hungary
por: Papp, Janos, et al.
Publicado: (2015)

A novel APC mosaicism in a patient with familial adenomatous polyposis
por: Iwaizumi, Moriya, et al.
Publicado: (2015)

A metabolic switch controls intestinal differentiation downstream of Adenomatous polyposis coli (APC)
por: Sandoval, Imelda T, et al.
Publicado: (2017)

Identification of an APC Variant in a Patient with Clinical Attenuated Familial Adenomatous Polyposis
por: Schlussel, Andrew T., et al.
Publicado: (2014)

TALEN-mediated apc mutation in Xenopus tropicalis phenocopies familial adenomatous polyposis
por: Van Nieuwenhuysen, Tom, et al.
Publicado: (2015)

Three novel mutations of APC gene in Chinese patients with familial adenomatous polyposis
por: Liu, Qi, et al.
Publicado: (2016)

Somatic Mutation of the APC Gene in Thyroid Carcinoma Associated with Familial Adenomatous Polyposis
por: Iwama, Takeo, et al.
Publicado: (1999)

Reduced expression of APC-1B but not APC-1A by the deletion of promoter 1B is responsible for familial adenomatous polyposis
por: Yamaguchi, Kiyoshi, et al.
Publicado: (2016)

Adenomatous Polyposis Coli (APC) regulates miR17-92 cluster through β-catenin pathway in colorectal cancer
por: Li, Yajuan, et al.
Publicado: (2016)

Molecular analysis of mutations for the adenomatous polyposis coli (APC) gene in Romanian patients with colorectal cancer
por: Toma, M, et al.
Publicado: (2008)

A novel mutation of adenomatous polyposis coli (APC) gene results in the formation of supernumerary teeth
por: Yu, Fang, et al.
Publicado: (2017)

Two different nucleotide substitutions of APC gene in a family with familial adenomatous polyposis
por: Eser, Betul, et al.
Publicado: (2015)

Somatic APC mosaicism and oligogenic inheritance in genetically unsolved colorectal adenomatous polyposis patients
por: Ciavarella, Michele, et al.
Publicado: (2018)

Modeling APC mutagenesis and familial adenomatous polyposis using human iPS cells
por: Sommer, Cesar A., et al.
Publicado: (2018)

APC mosaicism in a young woman with desmoid type fibromatosis and familial adenomatous polyposis
por: Stormorken, Astrid Tenden, et al.
Publicado: (2018)

Pseudoexons provide a mechanism for allele-specific expression of APC in familial adenomatous polyposis
por: Nieminen, Taina T., et al.
Publicado: (2016)

Novel Pathogenic Germline Variant of the Adenomatous Polyposis Coli (APC) Gene, p.S2627Gfs*12 Identified in a Mild Phenotype of APC-Associated Polyposis: A Case Report
por: Koeller, Diane R., et al.
Publicado: (2020)

Aberrant methylation of the Adenomatous Polyposis Coli (APC) gene promoter is associated with the inflammatory breast cancer phenotype
por: Van der Auwera, I, et al.
Publicado: (2008)

Adenomatous Polyposis Coli (APC) Protein Moves along Microtubules and Concentrates at Their Growing Ends in Epithelial Cells
por: Mimori-Kiyosue, Yuko, et al.
Publicado: (2000)

Therapeutic targeting truncated adenomatous polyposis coli (APC) proteins for the selective killing of colorectal cancer cells
por: Zhang, Lu, et al.
Publicado: (2014)

Tumour Suppressor Adenomatous Polyposis Coli (APC) localisation is regulated by both Kinesin-1 and Kinesin-2
por: Ruane, Peter T., et al.
Publicado: (2016)

Curated multiple sequence alignment for the Adenomatous Polyposis Coli (APC) gene and accuracy of in silico pathogenicity predictions
por: Karabachev, Alexander D., et al.
Publicado: (2020)

The Tumor Suppressor Adenomatous Polyposis Coli (apc) Is Required for Neural Crest-Dependent Craniofacial Development in Zebrafish
por: Liu, Xiaolei, et al.
Publicado: (2023)

Coinheritance of germline mutations in APC and MUTYH genes defines the clinical outcome of adenomatous polyposis syndromes
por: Forte, Giovanna, et al.
Publicado: (2022)

Genotype–Phenotype Correlations in Autosomal Dominant and Recessive APC Mutation-Negative Colorectal Adenomatous Polyposis
por: Zhu, Li-Hua, et al.
Publicado: (2023)

Identification of a novel CNV at the APC gene in a Chinese family with familial adenomatous polyposis
por: Li, Juyi, et al.
Publicado: (2023)

T cell migration and effector function differences in familial adenomatous polyposis patients with APC gene mutations
por: Cuche, Céline, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_r8tf7prjkgge2e6to11irc2qbo