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The Emerging Role of D-2-Hydroxyglutarate as an Oncometabolite in Hematolymphoid and Central Nervous System Neoplasms

Approximately 20% of unselected cases and 30% cytogenetically diploid cases of acute myeloid leukemia (AML) and 80% of grade II–III gliomas and secondary glioblastomas carry mutations in the isocitrate dehydrogenase (IDH) 1 and 2 genes. IDH1/2 mutations prevent oxidative decarboxylation of isocitrat...

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Detalles Bibliográficos
Autores principales:	Rakheja, Dinesh, Medeiros, L. Jeffrey, Bevan, Scott, Chen, Weina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2013
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698461/ https://www.ncbi.nlm.nih.gov/pubmed/23847760 http://dx.doi.org/10.3389/fonc.2013.00169

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