Cargando…

Biochemical and Anthropometric Effects of a Weight Loss Dietary Supplement in Healthy Men and Women

BACKGROUND: We have recently noted an acute increase in circulating free fatty acids and glycerol, as well as resting metabolic rate, when men and women ingested the dietary supplement OxyELITE Pro™ in a single dose. We have also noted a reduction in appetite when subjects were treated with this sup...

Descripción completa

Detalles Bibliográficos
Autores principales: McCarthy, Cameron G., Canale, Robert E., Alleman, Rick J., Reed, Jacob P., Bloomer, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698475/
https://www.ncbi.nlm.nih.gov/pubmed/23882144
http://dx.doi.org/10.4137/NMI.S8566
_version_ 1782275295489818624
author McCarthy, Cameron G.
Canale, Robert E.
Alleman, Rick J.
Reed, Jacob P.
Bloomer, Richard J.
author_facet McCarthy, Cameron G.
Canale, Robert E.
Alleman, Rick J.
Reed, Jacob P.
Bloomer, Richard J.
author_sort McCarthy, Cameron G.
collection PubMed
description BACKGROUND: We have recently noted an acute increase in circulating free fatty acids and glycerol, as well as resting metabolic rate, when men and women ingested the dietary supplement OxyELITE Pro™ in a single dose. We have also noted a reduction in appetite when subjects were treated with this supplement for 14 consecutive days. It is possible that such findings may favor body weight and fat loss over time. Therefore, the purpose of the present study was to determine the effects of this dietary supplement on weight loss and associated markers using an eight week intervention. METHODS: Exercise-trained subjects were randomly assigned in double blind manner to ingest either the dietary supplement (n = 16; aged 22.8 ± 0.7) or a placebo (n = 16; 22.5 ± 0.5) every day for eight weeks. Body weight, body composition, skinfold thickness, serum lipids, and appetite were measured as the primary outcome variables. As measures of supplement safety, a complete blood count and comprehensive metabolic panel were performed, and resting heart rate and blood pressure were measured (pre and post intervention). RESULTS: No interactions or main effects were noted for our primary outcome measures (P > 0.05). However, when comparing pre and post intervention values for the supplement, significant decreases were noted in appetite, body weight, body fat percentage, and skinfold thickness (P < 0.05), while increases were noted for total and HDL-C, as well as for resting heart rate (P < 0.05). No changes were noted for placebo from pre to post intervention (P > 0.05), with the exception of an increase in HDL-C (P < 0.05). Blood pressure and bloodborne safety variables were not differently impacted by supplement or placebo (P > 0.05), with the exception of monocytes, for which an interaction effect was noted (P = 0.04). CONCLUSION: These data indicate that the dietary supplement OxyELITE Pro™ may assist in weight and body fat loss in a sample of exercise-trained men and women. The supplement does not result in any adverse effects pertaining to resting blood pressure or bloodborne markers of safety; however a small increase in resting heart rate is observed.
format Online
Article
Text
id pubmed-3698475
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Libertas Academica
record_format MEDLINE/PubMed
spelling pubmed-36984752013-07-23 Biochemical and Anthropometric Effects of a Weight Loss Dietary Supplement in Healthy Men and Women McCarthy, Cameron G. Canale, Robert E. Alleman, Rick J. Reed, Jacob P. Bloomer, Richard J. Nutr Metab Insights Original Research BACKGROUND: We have recently noted an acute increase in circulating free fatty acids and glycerol, as well as resting metabolic rate, when men and women ingested the dietary supplement OxyELITE Pro™ in a single dose. We have also noted a reduction in appetite when subjects were treated with this supplement for 14 consecutive days. It is possible that such findings may favor body weight and fat loss over time. Therefore, the purpose of the present study was to determine the effects of this dietary supplement on weight loss and associated markers using an eight week intervention. METHODS: Exercise-trained subjects were randomly assigned in double blind manner to ingest either the dietary supplement (n = 16; aged 22.8 ± 0.7) or a placebo (n = 16; 22.5 ± 0.5) every day for eight weeks. Body weight, body composition, skinfold thickness, serum lipids, and appetite were measured as the primary outcome variables. As measures of supplement safety, a complete blood count and comprehensive metabolic panel were performed, and resting heart rate and blood pressure were measured (pre and post intervention). RESULTS: No interactions or main effects were noted for our primary outcome measures (P > 0.05). However, when comparing pre and post intervention values for the supplement, significant decreases were noted in appetite, body weight, body fat percentage, and skinfold thickness (P < 0.05), while increases were noted for total and HDL-C, as well as for resting heart rate (P < 0.05). No changes were noted for placebo from pre to post intervention (P > 0.05), with the exception of an increase in HDL-C (P < 0.05). Blood pressure and bloodborne safety variables were not differently impacted by supplement or placebo (P > 0.05), with the exception of monocytes, for which an interaction effect was noted (P = 0.04). CONCLUSION: These data indicate that the dietary supplement OxyELITE Pro™ may assist in weight and body fat loss in a sample of exercise-trained men and women. The supplement does not result in any adverse effects pertaining to resting blood pressure or bloodborne markers of safety; however a small increase in resting heart rate is observed. Libertas Academica 2011-12-06 /pmc/articles/PMC3698475/ /pubmed/23882144 http://dx.doi.org/10.4137/NMI.S8566 Text en © the author(s), publisher and licensee Libertas Academica Ltd. This is an open access article. Unrestricted non-commercial use is permitted provided the original work is properly cited.
spellingShingle Original Research
McCarthy, Cameron G.
Canale, Robert E.
Alleman, Rick J.
Reed, Jacob P.
Bloomer, Richard J.
Biochemical and Anthropometric Effects of a Weight Loss Dietary Supplement in Healthy Men and Women
title Biochemical and Anthropometric Effects of a Weight Loss Dietary Supplement in Healthy Men and Women
title_full Biochemical and Anthropometric Effects of a Weight Loss Dietary Supplement in Healthy Men and Women
title_fullStr Biochemical and Anthropometric Effects of a Weight Loss Dietary Supplement in Healthy Men and Women
title_full_unstemmed Biochemical and Anthropometric Effects of a Weight Loss Dietary Supplement in Healthy Men and Women
title_short Biochemical and Anthropometric Effects of a Weight Loss Dietary Supplement in Healthy Men and Women
title_sort biochemical and anthropometric effects of a weight loss dietary supplement in healthy men and women
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698475/
https://www.ncbi.nlm.nih.gov/pubmed/23882144
http://dx.doi.org/10.4137/NMI.S8566
work_keys_str_mv AT mccarthycamerong biochemicalandanthropometriceffectsofaweightlossdietarysupplementinhealthymenandwomen
AT canaleroberte biochemicalandanthropometriceffectsofaweightlossdietarysupplementinhealthymenandwomen
AT allemanrickj biochemicalandanthropometriceffectsofaweightlossdietarysupplementinhealthymenandwomen
AT reedjacobp biochemicalandanthropometriceffectsofaweightlossdietarysupplementinhealthymenandwomen
AT bloomerrichardj biochemicalandanthropometriceffectsofaweightlossdietarysupplementinhealthymenandwomen