From human genome to cancer genome: The first decade

The realization that cancer progression required the participation of cellular genes provided one of several key rationales, in 1986, for embarking on the human genome project. Only with a reference genome sequence could the full spectrum of somatic changes leading to cancer be understood. Since its...

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Detalles Bibliográficos
Autores principales: Wheeler, David A., Wang, Linghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2013
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698498/
https://www.ncbi.nlm.nih.gov/pubmed/23817046
http://dx.doi.org/10.1101/gr.157602.113
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author Wheeler, David A.
Wang, Linghua
author_facet Wheeler, David A.
Wang, Linghua
author_sort Wheeler, David A.
collection PubMed
description The realization that cancer progression required the participation of cellular genes provided one of several key rationales, in 1986, for embarking on the human genome project. Only with a reference genome sequence could the full spectrum of somatic changes leading to cancer be understood. Since its completion in 2003, the human reference genome sequence has fulfilled its promise as a foundational tool to illuminate the pathogenesis of cancer. Herein, we review the key historical milestones in cancer genomics since the completion of the genome, and some of the novel discoveries that are shaping our current understanding of cancer.
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spelling pubmed-36984982014-01-01 From human genome to cancer genome: The first decade Wheeler, David A. Wang, Linghua Genome Res Perspective The realization that cancer progression required the participation of cellular genes provided one of several key rationales, in 1986, for embarking on the human genome project. Only with a reference genome sequence could the full spectrum of somatic changes leading to cancer be understood. Since its completion in 2003, the human reference genome sequence has fulfilled its promise as a foundational tool to illuminate the pathogenesis of cancer. Herein, we review the key historical milestones in cancer genomics since the completion of the genome, and some of the novel discoveries that are shaping our current understanding of cancer. Cold Spring Harbor Laboratory Press 2013-07 /pmc/articles/PMC3698498/ /pubmed/23817046 http://dx.doi.org/10.1101/gr.157602.113 Text en © 2013, Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported), as described at http://creativecommons.org/licenses/by-nc/3.0/.
spellingShingle Perspective
Wheeler, David A.
Wang, Linghua
From human genome to cancer genome: The first decade
title From human genome to cancer genome: The first decade
title_full From human genome to cancer genome: The first decade
title_fullStr From human genome to cancer genome: The first decade
title_full_unstemmed From human genome to cancer genome: The first decade
title_short From human genome to cancer genome: The first decade
title_sort from human genome to cancer genome: the first decade
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698498/
https://www.ncbi.nlm.nih.gov/pubmed/23817046
http://dx.doi.org/10.1101/gr.157602.113
work_keys_str_mv AT wheelerdavida fromhumangenometocancergenomethefirstdecade
AT wanglinghua fromhumangenometocancergenomethefirstdecade

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