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Insights into neural crest development and evolution from genomic analysis
The neural crest is an excellent model system for the study of cell type diversification during embryonic development due to its multipotency, motility, and ability to form a broad array of derivatives ranging from neurons and glia, to cartilage, bone, and melanocytes. As a uniquely vertebrate cell...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698500/ https://www.ncbi.nlm.nih.gov/pubmed/23817048 http://dx.doi.org/10.1101/gr.157586.113 |
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author | Simões-Costa, Marcos Bronner, Marianne E. |
author_facet | Simões-Costa, Marcos Bronner, Marianne E. |
author_sort | Simões-Costa, Marcos |
collection | PubMed |
description | The neural crest is an excellent model system for the study of cell type diversification during embryonic development due to its multipotency, motility, and ability to form a broad array of derivatives ranging from neurons and glia, to cartilage, bone, and melanocytes. As a uniquely vertebrate cell population, it also offers important clues regarding vertebrate origins. In the past 30 yr, introduction of recombinant DNA technology has facilitated the dissection of the genetic program controlling neural crest development and has provided important insights into gene regulatory mechanisms underlying cell migration and differentiation. More recently, new genomic approaches have provided a platform and tools that are changing the depth and breadth of our understanding of neural crest development at a “systems” level. Such advances provide an insightful view of the regulatory landscape of neural crest cells and offer a new perspective on developmental as well as stem cell and cancer biology. |
format | Online Article Text |
id | pubmed-3698500 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Cold Spring Harbor Laboratory Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-36985002014-01-01 Insights into neural crest development and evolution from genomic analysis Simões-Costa, Marcos Bronner, Marianne E. Genome Res Perspective The neural crest is an excellent model system for the study of cell type diversification during embryonic development due to its multipotency, motility, and ability to form a broad array of derivatives ranging from neurons and glia, to cartilage, bone, and melanocytes. As a uniquely vertebrate cell population, it also offers important clues regarding vertebrate origins. In the past 30 yr, introduction of recombinant DNA technology has facilitated the dissection of the genetic program controlling neural crest development and has provided important insights into gene regulatory mechanisms underlying cell migration and differentiation. More recently, new genomic approaches have provided a platform and tools that are changing the depth and breadth of our understanding of neural crest development at a “systems” level. Such advances provide an insightful view of the regulatory landscape of neural crest cells and offer a new perspective on developmental as well as stem cell and cancer biology. Cold Spring Harbor Laboratory Press 2013-07 /pmc/articles/PMC3698500/ /pubmed/23817048 http://dx.doi.org/10.1101/gr.157586.113 Text en © 2013, Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported), as described at http://creativecommons.org/licenses/by-nc/3.0/. |
spellingShingle | Perspective Simões-Costa, Marcos Bronner, Marianne E. Insights into neural crest development and evolution from genomic analysis |
title | Insights into neural crest development and evolution from genomic analysis |
title_full | Insights into neural crest development and evolution from genomic analysis |
title_fullStr | Insights into neural crest development and evolution from genomic analysis |
title_full_unstemmed | Insights into neural crest development and evolution from genomic analysis |
title_short | Insights into neural crest development and evolution from genomic analysis |
title_sort | insights into neural crest development and evolution from genomic analysis |
topic | Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698500/ https://www.ncbi.nlm.nih.gov/pubmed/23817048 http://dx.doi.org/10.1101/gr.157586.113 |
work_keys_str_mv | AT simoescostamarcos insightsintoneuralcrestdevelopmentandevolutionfromgenomicanalysis AT bronnermariannee insightsintoneuralcrestdevelopmentandevolutionfromgenomicanalysis |