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Comprehensive genome- and transcriptome-wide analyses of mutations associated with microsatellite instability in Korean gastric cancers

Microsatellite instability (MSI) is a critical mechanism that drives genetic aberrations in cancer. To identify the entire MS mutation, we performed the first comprehensive genome- and transcriptome-wide analyses of mutations associated with MSI in Korean gastric cancer cell lines and primary tissue...

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Autores principales: Yoon, Kwiyeom, Lee, Sunghoon, Han, Tae-Su, Moon, So Yeon, Yun, Sun Mi, Kong, Seong-Ho, Jho, Sungwoong, Choe, Jinny, Yu, Jieun, Lee, Hyuk-Joon, Park, Ji Hyun, Kim, Hak-Min, Lee, So Yeun, Park, Jongsun, Kim, Woo-Ho, Bhak, Jong, Yang, Han-Kwang, Kim, Seong-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698504/
https://www.ncbi.nlm.nih.gov/pubmed/23737375
http://dx.doi.org/10.1101/gr.145706.112
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author Yoon, Kwiyeom
Lee, Sunghoon
Han, Tae-Su
Moon, So Yeon
Yun, Sun Mi
Kong, Seong-Ho
Jho, Sungwoong
Choe, Jinny
Yu, Jieun
Lee, Hyuk-Joon
Park, Ji Hyun
Kim, Hak-Min
Lee, So Yeun
Park, Jongsun
Kim, Woo-Ho
Bhak, Jong
Yang, Han-Kwang
Kim, Seong-Jin
author_facet Yoon, Kwiyeom
Lee, Sunghoon
Han, Tae-Su
Moon, So Yeon
Yun, Sun Mi
Kong, Seong-Ho
Jho, Sungwoong
Choe, Jinny
Yu, Jieun
Lee, Hyuk-Joon
Park, Ji Hyun
Kim, Hak-Min
Lee, So Yeun
Park, Jongsun
Kim, Woo-Ho
Bhak, Jong
Yang, Han-Kwang
Kim, Seong-Jin
author_sort Yoon, Kwiyeom
collection PubMed
description Microsatellite instability (MSI) is a critical mechanism that drives genetic aberrations in cancer. To identify the entire MS mutation, we performed the first comprehensive genome- and transcriptome-wide analyses of mutations associated with MSI in Korean gastric cancer cell lines and primary tissues. We identified 18,377 MS mutations of five or more repeat nucleotides in coding sequences and untranslated regions of genes, and discovered 139 individual genes whose expression was down-regulated in association with UTR MS mutation. In addition, we found that 90.5% of MS mutations with deletions in gene regions occurred in UTRs. This analysis emphasizes the genetic diversity of MSI-H gastric tumors and provides clues to the mechanistic basis of instability in microsatellite unstable gastric cancers.
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spelling pubmed-36985042014-01-01 Comprehensive genome- and transcriptome-wide analyses of mutations associated with microsatellite instability in Korean gastric cancers Yoon, Kwiyeom Lee, Sunghoon Han, Tae-Su Moon, So Yeon Yun, Sun Mi Kong, Seong-Ho Jho, Sungwoong Choe, Jinny Yu, Jieun Lee, Hyuk-Joon Park, Ji Hyun Kim, Hak-Min Lee, So Yeun Park, Jongsun Kim, Woo-Ho Bhak, Jong Yang, Han-Kwang Kim, Seong-Jin Genome Res Research Microsatellite instability (MSI) is a critical mechanism that drives genetic aberrations in cancer. To identify the entire MS mutation, we performed the first comprehensive genome- and transcriptome-wide analyses of mutations associated with MSI in Korean gastric cancer cell lines and primary tissues. We identified 18,377 MS mutations of five or more repeat nucleotides in coding sequences and untranslated regions of genes, and discovered 139 individual genes whose expression was down-regulated in association with UTR MS mutation. In addition, we found that 90.5% of MS mutations with deletions in gene regions occurred in UTRs. This analysis emphasizes the genetic diversity of MSI-H gastric tumors and provides clues to the mechanistic basis of instability in microsatellite unstable gastric cancers. Cold Spring Harbor Laboratory Press 2013-07 /pmc/articles/PMC3698504/ /pubmed/23737375 http://dx.doi.org/10.1101/gr.145706.112 Text en © 2013, Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported), as described at http://creativecommons.org/licenses/by-nc/3.0/.
spellingShingle Research
Yoon, Kwiyeom
Lee, Sunghoon
Han, Tae-Su
Moon, So Yeon
Yun, Sun Mi
Kong, Seong-Ho
Jho, Sungwoong
Choe, Jinny
Yu, Jieun
Lee, Hyuk-Joon
Park, Ji Hyun
Kim, Hak-Min
Lee, So Yeun
Park, Jongsun
Kim, Woo-Ho
Bhak, Jong
Yang, Han-Kwang
Kim, Seong-Jin
Comprehensive genome- and transcriptome-wide analyses of mutations associated with microsatellite instability in Korean gastric cancers
title Comprehensive genome- and transcriptome-wide analyses of mutations associated with microsatellite instability in Korean gastric cancers
title_full Comprehensive genome- and transcriptome-wide analyses of mutations associated with microsatellite instability in Korean gastric cancers
title_fullStr Comprehensive genome- and transcriptome-wide analyses of mutations associated with microsatellite instability in Korean gastric cancers
title_full_unstemmed Comprehensive genome- and transcriptome-wide analyses of mutations associated with microsatellite instability in Korean gastric cancers
title_short Comprehensive genome- and transcriptome-wide analyses of mutations associated with microsatellite instability in Korean gastric cancers
title_sort comprehensive genome- and transcriptome-wide analyses of mutations associated with microsatellite instability in korean gastric cancers
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698504/
https://www.ncbi.nlm.nih.gov/pubmed/23737375
http://dx.doi.org/10.1101/gr.145706.112
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