T cell–derived inducible nitric oxide synthase switches off T(H)17 cell differentiation

RORγt is necessary for the generation of T(H)17 cells but the molecular mechanisms for the regulation of T(H)17 cells are still not fully understood. We show that activation of CD4(+) T cells results in the expression of inducible nitric oxide synthase (iNOS). iNOS-deficient mice displayed enhanced...

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Detalles Bibliográficos
Autores principales: Yang, Jianjun, Zhang, Ruihua, Lu, Geming, Shen, Yu, Peng, Liang, Zhu, Chen, Cui, Miao, Wang, Weidong, Arnaboldi, Paul, Tang, Meng, Gupta, Monica, Qi, Chen-Feng, Jayaraman, Padmini, Zhu, Hongfa, Jiang, Bo, Chen, Shu-hsia, He, John Cijiang, Ting, Adrian T., Zhou, Ming-Ming, Kuchroo, Vijay K., Morse, Herbert C., Ozato, Keiko, Sikora, Andrew G., Xiong, Huabao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698516/
https://www.ncbi.nlm.nih.gov/pubmed/23797094
http://dx.doi.org/10.1084/jem.20122494

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