Cargando…

AP4 is a mediator of epithelial–mesenchymal transition and metastasis in colorectal cancer

The basic helix-loop-helix transcription factor AP4/TFAP4/AP-4 is encoded by a c-MYC target gene and displays up-regulation concomitantly with c-MYC in colorectal cancer (CRC) and numerous other tumor types. Here a genome-wide characterization of AP4 DNA binding and mRNA expression was performed usi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jackstadt, Rene, Röh, Simone, Neumann, Jens, Jung, Peter, Hoffmann, Reinhard, Horst, David, Berens, Christian, Bornkamm, Georg W., Kirchner, Thomas, Menssen, Antje, Hermeking, Heiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698521/ https://www.ncbi.nlm.nih.gov/pubmed/23752226 http://dx.doi.org/10.1084/jem.20120812

Ejemplares similares

AP4 is required for mitogen- and c-MYC-induced cell cycle progression
por: Jackstadt, Rene, et al.
Publicado: (2014)

c-MYC and SIRT1 locked in a vicious cycle
por: Menssen, Antje, et al.
Publicado: (2012)

Ap4 is rate limiting for intestinal tumor formation by controlling the homeostasis of intestinal stem cells
por: Jaeckel, Stephanie, et al.
Publicado: (2018)

AP4 directly downregulates p16 and p21 to suppress senescence and mediate transformation
por: Jackstadt, R, et al.
Publicado: (2013)

CYB5R1 links epithelial-mesenchymal transition and poor prognosis in colorectal cancer
por: Woischke, Christine, et al.
Publicado: (2016)

Inducible microRNA expression by an all-in-one episomal vector system
por: Epanchintsev, Alexey, et al.
Publicado: (2006)

Colorectal Cancers Mimic Structural Organization of Normal Colonic Crypts
por: Cernat, Laura, et al.
Publicado: (2014)

Repression of c-Kit by p53 is mediated by miR-34 and is associated with reduced chemoresistance, migration and stemness
por: Siemens, Helge, et al.
Publicado: (2013)

p53 directly activates cystatin D/CST5 to mediate mesenchymal-epithelial transition: a possible link to tumor suppression by vitamin D3
por: Hünten, Sabine, et al.
Publicado: (2015)

Microsatellite Instability, KRAS Mutations and Cellular Distribution of TRAIL-Receptors in Early Stage Colorectal Cancer
por: Kriegl, Lydia, et al.
Publicado: (2012)

c-MYC-Induced AP4 Attenuates DREAM-Mediated Repression by p53
por: Kaller, Markus, et al.
Publicado: (2023)

Paracrine Induction of Epithelial-Mesenchymal Transition Between Colorectal Cancer Cells and its Suppression by a p53/miR-192/215/NID1 Axis
por: Rokavec, Matjaz, et al.
Publicado: (2019)

Cdk3-promoted epithelial-mesenchymal transition through activating AP-1 is involved in colorectal cancer metastasis
por: Lu, Jinping, et al.
Publicado: (2016)

USP22 drives colorectal cancer invasion and metastasis via epithelial-mesenchymal transition by activating AP4
por: Li, Yongmin, et al.
Publicado: (2017)

AP-2β inhibits hepatocellular carcinoma invasion and metastasis through Slug and Snail to suppress epithelial-mesenchymal transition
por: Yang, Liu, et al.
Publicado: (2018)

Silencing of RAD51AP1 suppresses epithelial–mesenchymal transition and metastasis in non‐small cell lung cancer
por: Wu, Yuanyuan, et al.
Publicado: (2019)

SMAD4 Loss Induces c-MYC–Mediated NLE1 Upregulation to Support Protein Biosynthesis, Colorectal Cancer Growth, and Metastasis
por: Loevenich, Leon P., et al.
Publicado: (2022)

Transcription Factor AP4 Mediates Cell Fate Decisions: To Divide, Age, or Die
por: Wong, Matthew Man-Kin, et al.
Publicado: (2021)

Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer
por: Kriegl, Lydia, et al.
Publicado: (2012)

Characterization of a p53/miR-34a/CSF1R/STAT3 Feedback Loop in Colorectal Cancer
por: Shi, Xiaolong, et al.
Publicado: (2020)

Epithelial–mesenchymal transition in tumor metastasis
por: Yeung, Kay T., et al.
Publicado: (2016)

Development and Validation of a 15-gene Expression Signature with Superior Prognostic Ability in Stage II Colorectal Cancer
por: Rokavec, Matjaz, et al.
Publicado: (2023)

Nidogen-1/NID1 Function and Regulation during Progression and Metastasis of Colorectal Cancer
por: Rokavec, Matjaz, et al.
Publicado: (2023)

Multicolor lineage tracing reveals clonal architecture and dynamics in colon cancer
por: Lamprecht, Sebastian, et al.
Publicado: (2017)

Epithelial-mesenchymal transition in breast cancer progression and metastasis
por: Wang, Yifan, et al.
Publicado: (2011)

Contribution of epithelial-mesenchymal transitions to organogenesis and cancer metastasis
por: Campbell, Kyra
Publicado: (2018)

Epithelial-to-Mesenchymal Transition in Metastasis: Focus on Laryngeal Carcinoma
por: Goulioumis, Anastasios, et al.
Publicado: (2022)

AP4 suppresses DNA damage, chromosomal instability and senescence via inducing MDC1/Mediator of DNA damage Checkpoint 1 and repressing MIR22HG/miR-22-3p
por: Chou, Jinjiang, et al.
Publicado: (2022)

Dual role of CASP8AP2/FLASH in regulating epithelial-to-mesenchymal transition plasticity (EMP)
por: Catalanotto, Madison, et al.
Publicado: (2023)

WNT signaling and distant metastasis in colon cancer through transcriptional activity of nuclear β-Catenin depend on active PI3K signaling
por: Ormanns, Steffen, et al.
Publicado: (2014)

Corepressor metastasis-associated protein 3 modulates epithelial-to-mesenchymal transition and metastasis
por: Du, Liang, et al.
Publicado: (2017)

Wnt-driven LARGE2 mediates laminin-adhesive O-glycosylation in human colonic epithelial cells and colorectal cancer
por: Dietinger, Vanessa, et al.
Publicado: (2020)

Epithelial Mesenchymal Transition in Drug Resistance and Metastasis of Lung Cancer
por: Nurwidya, Fariz, et al.
Publicado: (2012)

Epithelial‐mesenchymal transition in cancer metastasis through the lymphatic system
por: Karlsson, Mikael C., et al.
Publicado: (2017)

Control of Invasion by Epithelial-to-Mesenchymal Transition Programs during Metastasis
por: Pearson, Gray W.
Publicado: (2019)

TGF-β-Mediated Epithelial-Mesenchymal Transition and Cancer Metastasis
por: Hao, Yang, et al.
Publicado: (2019)

Vimentin Is at the Heart of Epithelial Mesenchymal Transition (EMT) Mediated Metastasis
por: Usman, Saima, et al.
Publicado: (2021)

Osteoclasts in Tumor Biology: Metastasis and Epithelial-Mesenchymal-Myeloid Transition
por: Behzatoglu, Kemal
Publicado: (2021)

Editorial: Molecular mechanisms of epithelial-mesenchymal transition in cancer metastasis
por: Amin, Amr, et al.
Publicado: (2022)

The FGFR1 inhibitor PD173074 induces mesenchymal–epithelial transition through the transcription factor AP-1
por: Nguyen, P T, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_u1koqo07722ln0lfb7ss0q7ej9